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中药补虚化瘀方对自身免疫性肝炎中Treg/Th17比例失衡的调节作用

Chinese medicine bu xu hua yu recipe for the regulation of treg/th17 ratio imbalance in autoimmune hepatitis.

作者信息

Wang Lei, Du Huihui, Liu Yibo, Wang Lingtai, Ma Xiong, Zhang Wei

机构信息

Department of Hepatology, Shanghai University of Traditional Chinese Medicine, Longhua Hospital, No. 725 South Wan Ping Road, Shanghai, China.

Department of Hepatology, Shanghai University of Traditional Chinese Medicine, Longhua Hospital, No. 725 South Wan Ping Road, Shanghai, China ; Shanghai University of Traditional Chinese Medicine, Shuguang Hospital, Shanghai, China.

出版信息

Evid Based Complement Alternat Med. 2015;2015:461294. doi: 10.1155/2015/461294. Epub 2015 Apr 21.

DOI:10.1155/2015/461294
PMID:25977698
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4419233/
Abstract

Objectives. The aim of this study is researching the role of the Regulatory T cell (Treg)/T helper cell-17 (Th17) cell ratio imbalance in the pathogenesis of autoimmune hepatitis (AIH) and the use of the "Bu Xu Hua Yu" recipe in the treatment of AIH. Materials and Methods. Sixty adult male C57/BL6 mice were divided into six different groups. α-Galcer was injected abdominally for production of the animal models. Liver function tests, histological examinations, liver tissue Regulatory T cell, and T helper cell-17 levels tests were carried out. TGF-β1, IL-10, IL-17, and expression of mRNA and protein levels of Foxp3 and ROR-γt were also assessed. Results. Bu Xu Hua Yu method increased the levels of Regulatory T cell, IL-10, and the expression of Foxp3 (P < 0.05) in mice liver tissues. Furthermore, there were decreases in the levels of T helper cell-17, IL-17, and expression of RORγt mRNA and protein (P < 0.05). The ratio of Treg/Th17 was increased (P < 0.05). Conclusion. Mice with AIH have a Treg/Th17 ratio imbalance. Bu Xu Hua Yu method was able to restore the cellular balance of Treg/Th17 through the regulation of the expression of RORγt and Foxp3 and can play an important role in the treatment of AIH.

摘要

目的。本研究旨在探讨调节性T细胞（Treg）/辅助性T细胞17（Th17）细胞比例失衡在自身免疫性肝炎（AIH）发病机制中的作用，以及“补虚化淤”方剂在AIH治疗中的应用。材料与方法。将60只成年雄性C57/BL6小鼠分为6个不同组。经腹腔注射α-半乳糖神经酰胺以建立动物模型。进行肝功能检测、组织学检查、肝组织调节性T细胞和辅助性T细胞17水平检测。还评估了转化生长因子-β1（TGF-β1）、白细胞介素-10（IL-10）、白细胞介素-17（IL-17）以及叉头框蛋白3（Foxp3）和维甲酸相关孤儿受体γt（ROR-γt）的mRNA和蛋白表达水平。结果。补虚化淤法可提高小鼠肝组织中调节性T细胞、IL-10水平以及Foxp3的表达（P<0.05）。此外，辅助性T细胞17、IL-17水平以及RORγt mRNA和蛋白表达均降低（P<0.05）。Treg/Th17比例升高（P<0.05）。结论。AIH小鼠存在Treg/Th17比例失衡。补虚化淤法可通过调节RORγt和Foxp3的表达恢复Treg/Th17的细胞平衡，在AIH治疗中发挥重要作用。

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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/eebd/4419233/4f1c4bb45c9b/ECAM2015-461294.006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/eebd/4419233/73be48877958/ECAM2015-461294.007.jpg
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