Korhonen Heidi J, Bolt Hannah L, Hodgson David R W
Department of Chemistry, Science Laboratories, Durham University, South Road, Durham, DH1 3LE, United Kingdom, ; Department of Chemistry, University of Turku, Vatselankatu 2, 20014 Turku, Finland.
Department of Chemistry, Science Laboratories, Durham University, South Road, Durham, DH1 3LE, United Kingdom.
Beilstein J Org Chem. 2015 Apr 10;11:469-72. doi: 10.3762/bjoc.11.52. eCollection 2015.
Tris[bis(triphenylphosphoranylidene)ammonium] pyrophosphate (PPN pyrophosphate) was used in the SN2 displacements of the tosylate ion from 5'-tosylnucleosides to afford nucleoside-5'-diphosphates. Selective precipitation permitted the direct isolation of nucleoside-5'-diphosphates from crude reaction mixtures.
焦磷酸三[双（三苯基磷亚基）铵]（PPN焦磷酸盐）用于使对甲苯磺酸根离子从5'-对甲苯磺酰核苷中发生SN2取代反应，以得到核苷-5'-二磷酸。选择性沉淀使得能够从粗反应混合物中直接分离出核苷-5'-二磷酸。
