Department of Chemistry, Georgia State University, Atlanta, Georgia, USA.
Chem Commun (Camb). 2011 Jul 28;47(28):8142-4. doi: 10.1039/c1cc12201k. Epub 2011 Jun 14.
By generating a selective phosphitylating reagent in situ, nucleoside 5'-triphosphates can be conveniently synthesized in one pot. This novel strategy without nucleoside protection has been developed to largely simplify synthesis of the nucleoside triphosphates. This demonstrated principle can be applied to the 5'-triphosphate synthesis of both native and modified nucleosides.
通过原位生成选择性膦酰化试剂，可以方便地一锅合成核苷 5′-三磷酸。这种无核苷保护的新策略大大简化了核苷三磷酸的合成。该原理可应用于天然和修饰核苷的 5′-三磷酸合成。
