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急诊科就诊的全身炎症反应综合征(SIRS)患者中,毛细血管乳酸作为分诊护士的工具:初步报告

Capillary lactate as a tool for the triage nurse among patients with SIRS at emergency department presentation: a preliminary report.

作者信息

Manzon Cyril, Barrot Loïc, Besch Guillaume, Barbot Olivier, Desmettre Thibaut, Capellier Gilles, Piton Gaël

机构信息

Medical Intensive Care Unit, Besançon University Hospital, Boulevard Fleming, 25030 Besançon, France.

Department of Anesthesiology and Intensive Care Medicine, Besançon University Hospital, Boulevard Fleming, 25030 Besançon, France.

出版信息

Ann Intensive Care. 2015 Apr 24;5:7. doi: 10.1186/s13613-015-0047-y. eCollection 2015.

Abstract

BACKGROUND

The triage nurse is involved in the early identification of the most severe patients at emergency department (ED) presentation. However, clinical criteria alone may be insufficient to identify them correctly. Measurement of capillary lactate concentration at ED presentation may help to discriminate these patients. The primary objective of this study was to identify the prognostic value of capillary lactate concentration measured by the triage nurse among patients presenting to the ED.

METHODS

This was a prospective observational study, performed in the ED of a university hospital. At ED presentation, capillary lactate measurement was performed by the triage nurse among patients presenting with a clinical criteria of systemic inflammatory response syndrome (SIRS). Clinical variables usually used to determine severity were collected at presentation. Twenty-eight-day mortality and MEDS score were recorded.

RESULTS

One hundred seventy-six patients with clinical SIRS presented to the ED. Median age was 72 years, and 28-day mortality was 16%. Capillary lactate at ED presentation was significantly higher among 28-day non-survivors than among survivors (5.7 mmol.L(-1) [3.2 to 7.4] vs 2.9 mmol.L(-1) [1.9 to 5.2], p = 0.003). A score based on mottling and capillary lactate concentration >3.6 mmol.L(-1) was significantly associated with 28-day mortality (area under curve, AUC = 0.75), independently of the MEDS score (AUC = 0.79) for the prediction of 28-day mortality (AUC global model 0.87).

CONCLUSIONS

A high capillary lactate concentration measured by the triage nurse among patients presenting to the ED with clinical SIRS is associated with a high risk of death. A score calculated by the triage nurse, based on mottling and capillary lactate concentration, appears to be useful for identifying the most severe patients.

摘要

背景

分诊护士参与在急诊科(ED)就诊时对最严重患者的早期识别。然而,仅靠临床标准可能不足以正确识别这些患者。在ED就诊时测量毛细血管乳酸浓度可能有助于鉴别这些患者。本研究的主要目的是确定分诊护士测量的毛细血管乳酸浓度在ED就诊患者中的预后价值。

方法

这是一项在大学医院急诊科进行的前瞻性观察性研究。在ED就诊时,分诊护士对符合全身炎症反应综合征(SIRS)临床标准的患者进行毛细血管乳酸测量。就诊时收集通常用于确定严重程度的临床变量。记录28天死亡率和MEDS评分。

结果

176例临床SIRS患者就诊于ED。中位年龄为72岁,28天死亡率为16%。28天非幸存者在ED就诊时的毛细血管乳酸水平显著高于幸存者(5.7 mmol·L⁻¹[3.2至7.4] vs 2.9 mmol·L⁻¹[1.9至5.2],p = 0.003)。基于皮肤斑纹和毛细血管乳酸浓度>3.6 mmol·L⁻¹的评分与28天死亡率显著相关(曲线下面积,AUC = 0.75),独立于预测28天死亡率的MEDS评分(AUC = 0.79)(AUC全局模型0.87)。

结论

分诊护士在ED就诊的临床SIRS患者中测量到的高毛细血管乳酸浓度与高死亡风险相关。分诊护士根据皮肤斑纹和毛细血管乳酸浓度计算的评分似乎有助于识别最严重的患者。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fc12/4414858/9b1e762b31f6/13613_2015_47_Fig1_HTML.jpg

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