Kim Moinay, Cheok Stephanie, Chung Lawrance K, Ung Nolan, Thill Kimberly, Voth Brittany, Kwon Do Hoon, Kim Jeong Hoon, Kim Chang Jin, Tenn Stephen, Lee Percy, Yang Isaac
Department of Neurosurgery, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea.
Department of Neurosurgery, University of California Los Angeles, Los Angeles, CA, USA.
Brain Tumor Res Treat. 2015 Apr;3(1):1-7. doi: 10.14791/btrt.2015.3.1.1. Epub 2015 Apr 29.
Brain metastasis represents one of the most common causes of intracranial tumors in adults, and the incidence of brain metastasis continues to rise due to the increasing survival of cancer patients. Yet, the development of cystic brain metastasis remains a relatively rare occurrence. In this review, we describe the characteristics of cystic brain metastasis and evaluate the combined use of stereotactic aspiration and radiosurgery in treating large cystic brain metastasis. The results of several studies show that stereotactic radiosurgery produces comparable local tumor control and survival rates as other surgery protocols. When the size of the tumor interferes with radiosurgery, stereotactic aspiration of the metastasis should be considered to reduce the target volume as well as decreasing the chance of radiation induced necrosis and providing symptomatic relief from mass effect. The combined use of stereotactic aspiration and radiosurgery has strong implications in improving patient outcomes.
脑转移瘤是成人颅内肿瘤最常见的病因之一，由于癌症患者生存率的提高，脑转移瘤的发病率持续上升。然而，囊性脑转移瘤的发生仍然相对少见。在本综述中，我们描述了囊性脑转移瘤的特征，并评估了立体定向穿刺抽吸术和放射外科联合应用于治疗大型囊性脑转移瘤的效果。多项研究结果表明，立体定向放射外科与其他手术方案相比，在局部肿瘤控制和生存率方面具有可比性。当肿瘤大小影响放射外科治疗时，应考虑对转移瘤进行立体定向穿刺抽吸，以缩小靶体积，降低放射性坏死的几率，并缓解占位效应引起的症状。立体定向穿刺抽吸术和放射外科联合应用对改善患者预后具有重要意义。
