模拟植物中生长素细胞间运输极性模式的出现。
Modelling the emergence of polarity patterns for the intercellular transport of auxin in plants.
作者信息
Grigolon Silvia, Sollich Peter, Martin Olivier C
出版信息
J R Soc Interface. 2015 May 6;12(106). doi: 10.1098/rsif.2014.1223.
The hormone auxin is actively transported throughout plants via protein machineries including the dedicated transporter known as PIN. The associated transport is ordered with nearby cells driving auxin flux in similar directions. Here, we provide a model of both the auxin transport and of the dynamics of cellular polarization based on flux sensing. Our main findings are: (i) spontaneous intracellular PIN polarization arises if PIN recycling dynamics are sufficiently nonlinear, (ii) there is no need for an auxin concentration gradient and (iii) ordered multi-cellular patterns of PIN polarization are favoured by molecular noise.
植物激素生长素通过包括名为PIN的专用转运蛋白在内的蛋白质机制在整个植物中进行主动运输。相关的运输是有序的，附近的细胞以相似的方向驱动生长素流动。在这里，我们基于通量感应提供了一个生长素运输和细胞极化动力学的模型。我们的主要发现是：（i）如果PIN循环动力学足够非线性，就会出现自发的细胞内PIN极化；（ii）不需要生长素浓度梯度；（iii）分子噪声有利于PIN极化的有序多细胞模式。
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