Deng Fangge, Tang Qing, Zeng Guangqiao, Wu Hua, Zhang Nuofu, Zhong Nanshan
State Key Laboratory of Respiratory Disease, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou 510120, China.
Department of Ultrasound, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou 510120, China.
Med Phys. 2015 May;42(5):2242-8. doi: 10.1118/1.4907969.
The authors aimed to determine the effectiveness of infrared thermal imaging (IRTI) as a novel, noninvasive technique in adjunctive diagnostic screening for lower limb deep venous thrombosis (DVT).
The authors used an infrared thermal imaging sensor to examine the lower limbs of 64 DVT patients and 64 healthy volunteers. The DVT patients had been definitively diagnosed with either Doppler vascular compression ultrasonography or angiography. The mean area temperature (T_area) and mean linear temperature (T_line) in the region of interest were determined with infrared thermal imaging. Images were evaluated with qualitative pseudocolor analysis to verify specific color-temperature responses and with quantitative temperature analysis. Differences in T_area and T_line between the DVT limb and the nonaffected limb in each DVT patient and temperature differences (TDs) in T_area (TDarea) and T_line (TDline) between DVT patients and non-DVT volunteers were compared.
Qualitative pseudocolor analysis revealed visible asymmetry between the DVT side and non-DVT side in the presentation and distribution characteristics (PDCs) of infrared thermal images. The DVT limbs had areas of abnormally high temperature, indicating the presence of DVT. Of the 64 confirmed DVT patients, 62 (96.88%) were positive by IRTI detection. Among these 62 IRTI-positive cases, 53 (82.81%) showed PDCs that agreed with the DVT regions detected by Doppler vascular compression ultrasonography or angiography. In nine patients (14.06%), IRTI PDCs did not definitively agree with the DVT regions established with other testing methods, but still correctly indicated the DVT-affected limb. There was a highly significant difference between DVT and non-DVT sides in DVT patients (P < 0.01). The TDarea and TDline in non-DVT volunteers ranged from 0.19 ± 0.15 °C to 0.21 °C ± 0.17 °C; those in DVT patients ranged from 0.86 °C ± 0.71 °C to 1.03 °C ± 0.79 °C (P < 0.01).
Infrared thermal imaging can be effectively used in DVT detection and adjunctive diagnostic screening because of its specific infrared PDCs and TDs values.
作者旨在确定红外热成像（IRTI）作为一种新型非侵入性技术在下肢深静脉血栓形成（DVT）辅助诊断筛查中的有效性。
作者使用红外热成像传感器检查64例DVT患者和64名健康志愿者的下肢。这些DVT患者已通过多普勒血管压迫超声检查或血管造影明确诊断。用红外热成像确定感兴趣区域的平均面积温度（T_area）和平均线温度（T_line）。通过定性伪彩色分析评估图像以验证特定的色温响应，并进行定量温度分析。比较每位DVT患者患DVT肢体与未受影响肢体之间T_area和T_line的差异，以及DVT患者与非DVT志愿者之间T_area（TDarea）和T_line（TDline）的温度差异（TDs）。
定性伪彩色分析显示，红外热图像的呈现和分布特征（PDCs）在DVT侧和非DVT侧之间存在明显不对称。DVT肢体有异常高温区域，表明存在DVT。在64例确诊的DVT患者中，62例（96.88%）通过IRTI检测呈阳性。在这62例IRTI阳性病例中，53例（82.81%）的PDCs与多普勒血管压迫超声检查或血管造影检测到的DVT区域一致。在9例患者（14.06%）中，IRTI的PDCs与其他检测方法确定的DVT区域不完全一致，但仍正确指出了受DVT影响的肢体。DVT患者的DVT侧与非DVT侧之间存在高度显著差异（P < 0.01）。非DVT志愿者的TDarea和TDline范围为0.19±0.15°C至0.21°C±0.17°C；DVT患者的范围为0.86°C±0.71°C至1.03°C±0.79°C（P < 0.01）。
由于其特定的红外PDCs和TDs值，红外热成像可有效地用于DVT检测和辅助诊断筛查。
