Umezaki Y, Badran B W, Gonzales T S, George M S
Brain Stimulation Laboratory, Department of Psychiatry, Medical University of South Carolina, Charleston, SC, USA.
Brain Stimulation Laboratory, Department of Psychiatry, Medical University of South Carolina, Charleston, SC, USA.
Int J Oral Maxillofac Surg. 2015 Aug;44(8):1048-51. doi: 10.1016/j.ijom.2015.04.008. Epub 2015 Jun 5.
Burning mouth syndrome (BMS) is a persistent and chronic burning sensation in the mouth in the absence of any abnormal organic findings. The pathophysiology of BMS is unclear and its treatment is not fully established. Although antidepressant medication is commonly used for treatment, there are some medication-resistant patients, and a new treatment for medication-resistant BMS is needed. Repetitive transcranial magnetic stimulation (rTMS) is a non-invasive brain stimulation technology approved by the US Food and Drug Administration (FDA) for the treatment of depression. Recent studies have found beneficial effects of TMS for the treatment of pain. A case of BMS treated successfully with daily left prefrontal rTMS over a 2-week period is reported here. Based on this patient's clinical course and a recent pain study, the mechanism by which TMS may act to decrease the burning pain is discussed.
灼口综合征（BMS）是指在口腔内不存在任何异常器质性病变的情况下，出现持续的慢性灼痛感觉。BMS的病理生理学尚不清楚，其治疗方法也尚未完全确立。尽管抗抑郁药物常用于治疗，但仍有一些耐药患者，因此需要一种针对耐药性BMS的新治疗方法。重复经颅磁刺激（rTMS）是一种经美国食品药品监督管理局（FDA）批准用于治疗抑郁症的非侵入性脑刺激技术。最近的研究发现，经颅磁刺激对疼痛治疗有有益效果。本文报告了一例通过为期2周的每日左侧前额叶rTMS成功治疗的BMS病例。基于该患者的临床病程以及最近的一项疼痛研究，讨论了经颅磁刺激可能减轻灼痛的作用机制。
