Laboratory of Stem Cells and Cancer, Université Libre de Bruxelles (ULB), Brussels, Belgium.
WELBIO, ULB, Bruxelles, Belgium.
Nat Cancer. 2023 Aug;4(8):1063-1082. doi: 10.1038/s43018-023-00595-y. Epub 2023 Aug 3.
Cell plasticity represents the ability of cells to be reprogrammed and to change their fate and identity, enabling homeostasis restoration and tissue regeneration following damage. Cell plasticity also contributes to pathological conditions, such as cancer, enabling cells to acquire new phenotypic and functional features by transiting across distinct cell states that contribute to tumor initiation, progression, metastasis and resistance to therapy. Here, we review the intrinsic and extrinsic mechanisms driving cell plasticity that promote tumor growth and proliferation as well as metastasis and drug tolerance. Finally, we discuss how cell plasticity could be exploited for anti-cancer therapy.
细胞可塑性代表了细胞被重新编程以及改变其命运和特性的能力，使细胞能够在受损后恢复内稳态并进行组织再生。细胞可塑性也有助于病理状况，如癌症，使细胞能够通过跨越不同的细胞状态获得新的表型和功能特征，这些状态有助于肿瘤的起始、进展、转移和对治疗的耐药性。在这里，我们综述了促进肿瘤生长和增殖以及转移和药物耐受的内在和外在机制。最后，我们讨论了如何利用细胞可塑性进行抗癌治疗。
