Institute for Human Infections and Immunity, University of Texas Medical Branch, Galveston, TX 77555-0610, United States; Center for Tropical Diseases, University of Texas Medical Branch, Galveston, TX 77555-0609, United States; Department of Microbiology and Immunology, University of Texas Medical Branch, Galveston, TX 77555-0610, United States; Department of Pathology, University of Texas Medical Branch, Galveston, TX 77555-0610, United States; Global Virus Network, Baltimore, MD, United States.
Institute for Human Infections and Immunity, University of Texas Medical Branch, Galveston, TX 77555-0610, United States; Center for Tropical Diseases, University of Texas Medical Branch, Galveston, TX 77555-0609, United States; Department of Pathology, University of Texas Medical Branch, Galveston, TX 77555-0610, United States.
Antiviral Res. 2015 Aug;120:32-9. doi: 10.1016/j.antiviral.2015.04.016. Epub 2015 May 12.
Chikungunya virus (CHIKV) has a long history of emergence into urban transmission cycles from its ancestral, enzootic, sylvatic foci in Sub-Saharan Africa, most recently spreading to the Americas beginning in 2013. Since 2004, reemergence has resulted in millions of cases of severe, debilitating and often chronic arthralgia on five continents. Here, we review this history based on phylogenetic studies, and discuss probable future spread and disease in the Americas. We also discuss a series of mutations in the recently emerged Indian Ocean Lineage that has adapted the virus for transmission for the first time by the Aedes albopictus urban mosquito vector, and compare CHIKV to other arboviruses with and without similar histories of urbanization. This article forms part of a symposium in Antiviral Research on "Chikungunya discovers the New World."
基孔肯雅病毒（CHIKV）具有从其在撒哈拉以南非洲的祖传、地方性、森林地方性焦点进入城市传播周期的悠久历史，最近一次传播始于 2013 年开始传播到美洲。自 2004 年以来，重新出现导致全球五个大陆上数百万人出现严重、衰弱且常常是慢性关节炎。在这里，我们根据系统发育研究回顾了这段历史，并讨论了在美洲可能的未来传播和疾病。我们还讨论了最近出现的印度洋谱系中的一系列突变，这些突变使病毒首次通过白纹伊蚊这种城市蚊子传播媒介适应了传播，同时还将 CHIKV 与其他具有和不具有类似城市化历史的虫媒病毒进行了比较。本文是《抗病毒研究》关于“基孔肯雅病毒发现新世界”专题的一部分。
