Markevich L N, Kolomiytseva I K
Radiats Biol Radioecol. 2014 Nov-Dec;54(6):582-8.
The effect of a local exposure of rat heads to X-ray radiation at a dose of 200 Gy on the number of phospho- lipids and neutral lipids in the nuclear fraction ofneocortex neurons and glia has been investigated A decrease in the amount ofphosphatidylinositol and an increase in sphingomyelin in neuronal nuclei occurred 2 h after irradiation at the time of repair of locomotive disorders. The amount of phosphatidylcholine and phosphati- dylinositol dropped, and the amount of sphingomyelin and cholesterol increased in the nuclei ofglial cells of the neocortex. Sphingomyelin, phosphatidylinositol, phosphatidylcholine and cholesterol of neuronal nuclei are involved in the dynamics of the CNS syndrome in mammals. Radio resistance of the responses of lipid nuclei in mammals with the CNS syndrome has been shown and a possible role of lipids in the post-irradia- tion DNA repair has been suggested.
研究了以200 Gy的剂量对大鼠头部进行局部X射线辐射，对新皮质神经元和神经胶质细胞核部分中磷脂和中性脂质数量的影响。在修复运动障碍时，照射后2小时神经元细胞核中的磷脂酰肌醇量减少，鞘磷脂量增加。新皮质神经胶质细胞核中的磷脂酰胆碱和磷脂酰肌醇量下降，鞘磷脂和胆固醇量增加。神经元细胞核中的鞘磷脂、磷脂酰肌醇、磷脂酰胆碱和胆固醇参与哺乳动物中枢神经系统综合征的动态变化。已证明患有中枢神经系统综合征的哺乳动物脂质核反应具有放射抗性，并提出了脂质在辐射后DNA修复中的可能作用。
