Oyanagi K, Takahashi H, Wakabayashi K, Ikuta F
Center for Materials of Brain Diseases, Niigata University, Japan.
Brain Res. 1989 Dec 18;504(2):354-7. doi: 10.1016/0006-8993(89)91384-x.
A quantitative investigation was performed on the large neurons in the neostriatum and basal nucleus of Meynert (bnM) in patients with Alzheimer's disease (AD) and progressive supranuclear palsy (PSP). The degree of decrease of the large neurons in the neostriatum was quite similar to that in the bnM; these decreases were significantly correlative in AD, but not in PSP. These findings indicate that the large neurons in the neostriatum and bnM, which are considered to be cholinergic and to exclusively possess nerve growth factor receptors in the cerebrum, degenerate simultaneously in an equal ratio in AD.
对阿尔茨海默病（AD）和进行性核上性麻痹（PSP）患者的新纹状体及迈内特基底核（bnM）中的大神经元进行了定量研究。新纹状体中大神经元的减少程度与bnM中的相当；这些减少在AD中显著相关，但在PSP中不相关。这些发现表明，新纹状体和bnM中的大神经元，被认为是胆碱能的且在大脑中仅拥有神经生长因子受体，在AD中以相同比例同时退化。
