Tagliavini F, Pilleri G, Bouras C, Constantinidis J
Acta Neurol Scand. 1984 Jul;70(1):20-8. doi: 10.1111/j.1600-0404.1984.tb00798.x.
The basal nucleus of Meynert (bnM) was examined in 6 patients with idiopathic Parkinson's disease and in 5 age-matched controls. The histopathological study was followed by a quantitative analysis of the magnocellular population of the nucleus, with the determination of the number of neurons and their nucleolar volume. In Parkinson's disease, there was a neuronal loss ranging from 29.9% to 68.3% (mean 45.8%) and numerous surviving cells containing Lewy inclusion bodies. The percentage loss of cells did not display a significant correlation with the age of the patients, the duration of the illness, the mental state or the drug regime. On the other hand, no significant differences in nucleolar volume of bnM neurons were detected between patients and controls. The damage of the basal nucleus of Meynert in Parkinson's disease is less severe than that generally observed in Alzheimer's disease, and is slightly more pronounced than that reported for progressive supranuclear palsy.
对6例特发性帕金森病患者和5例年龄匹配的对照者的Meynert基底核（bnM）进行了检查。组织病理学研究之后，对该核的大细胞群体进行了定量分析，测定了神经元数量及其核仁体积。在帕金森病中，神经元丢失率为29.9%至68.3%（平均45.8%），且有大量含有路易小体的存活细胞。细胞丢失百分比与患者年龄、病程、精神状态或用药方案均无显著相关性。另一方面，患者与对照者之间bnM神经元的核仁体积未检测到显著差异。帕金森病中Meynert基底核的损伤程度不如阿尔茨海默病中通常观察到的严重，且比进行性核上性麻痹中报道的损伤稍明显。
