Tagliavini F, Pilleri G, Bouras C, Constantinidis J
Neurosci Lett. 1984 Jan 27;44(1):37-42. doi: 10.1016/0304-3940(84)90217-9.
The neuronal number and nucleolar volume of the magnocellular population of the basal nucleus of Meynert in 6 patients with progressive supranuclear palsy (PSP) - one associated with Alzheimer's disease - were compared with those of 5 controls. In the 5 typical PSP cases, an age-dependent neuronal loss was demonstrated ranging from 12.6% to 54.1%. In the PSP-Alzheimer patient, the loss of cells amounted to 73.8% and the surviving neurons exhibited a reduction in the nucleolar volume, suggesting a reduced protein synthetic capability. The involvement of the basal nucleus is therefore a usual anatomical feature of PSP. The damage is less severe than generally observed in Alzheimer's disease and biochemical studies are required to state whether this is accompanied by a substantial cholinergic deficit.
将6例进行性核上性麻痹（PSP）患者（其中1例合并阿尔茨海默病）Meynert基底核大细胞群的神经元数量和核仁体积与5例对照者进行比较。在5例典型的PSP病例中，发现存在年龄依赖性神经元丢失，范围为12.6%至54.1%。在合并阿尔茨海默病的PSP患者中，细胞丢失达73.8%，存活神经元的核仁体积减小，提示蛋白质合成能力降低。因此，基底核受累是PSP常见的解剖学特征。这种损害不如阿尔茨海默病中通常观察到的严重，需要进行生化研究来确定是否伴有大量胆碱能缺乏。
