Second Division of Interventional Cardiology, Onassis Cardiac Surgery Center, Athens, Greece.
Expert Rev Mol Diagn. 2015;15(7):965-70. doi: 10.1586/14737159.2015.1042367. Epub 2015 May 17.
The authors investigated whether neutrophil to lymphocyte ratio (N/L) can contribute to the diagnosis and risk assessment in patients with type A acute aortic dissection (AAD).
The authors studied 120 consecutive patients with type A AAD (group I) and compared them with 121 consecutive patients with chronic aneurysms (group II) and 121 age- and sex-matched healthy subjects (group III).
It was found that white blood cell count, N/L, D-dimer and C-reactive protein were significantly higher in group I versus both groups II and III (p < 0.001 for all comparisons). White blood cell count and D-dimer were much higher in patients who died compared to survivors in group I (p = 0.023 and p = 0.033, respectively). A cutoff value of N/L >4.6 was associated with 0.89 sensitivity and 0.91 specificity for AAD.
High N/L may contribute to the diagnostic evaluation and prompt immediate therapy in patients with type A AAD.
作者研究中性粒细胞与淋巴细胞比值（N/L）是否可以有助于诊断和评估 A 型急性主动脉夹层（AAD）患者的风险。
作者研究了 120 例连续的 A 型 AAD 患者（I 组），并与 121 例连续的慢性动脉瘤患者（II 组）和 121 例年龄和性别匹配的健康受试者（III 组）进行比较。
发现 I 组的白细胞计数、N/L、D-二聚体和 C 反应蛋白均明显高于 II 组和 III 组（所有比较均为 p < 0.001）。与 I 组幸存者相比，死亡患者的白细胞计数和 D-二聚体更高（p = 0.023 和 p = 0.033）。N/L > 4.6 的截断值与 AAD 的 0.89 敏感性和 0.91 特异性相关。
高 N/L 可能有助于诊断评估和及时治疗 A 型 AAD 患者。
