不只是大小：杂化树枝状纳米载体的挑战与机遇。
More than Just Size: Challenges and Opportunities of Hybrid Dendritic Nanocarriers.
机构信息
Instituto de Investigación y Desarrollo en Ingeniería de Procesos y Química Aplicada (IPQA), CONICET. Departamento de Química Orgánica. Facultad de Ciencias Químicas, Universidad Nacional de Córdoba. Córdoba. Argentina.
Instituto de Investigaciones en Físico Química de Córdoba (INFIQC), CONICET. Departamento de Físico-Química. Facultad de Ciencias Químicas, Universidad Nacional de Córdoba. Córdoba. Argentina.
出版信息
Curr Pharm Des. 2017;23(21):3142-3153. doi: 10.2174/1381612823666170407162725.
BACKGROUND
Dendrimers and hyperbranched polymers are emerging polymer architectures that attract increasing attention due to their unique topological structure and interesting physicochemical properties. Their enormous potential makes them particularly attractive to form new and fascinating nanometric drug delivery systems, solving several typical shortcomings encountered in nanomedicine.
OBJECTIVE
In this context, the recent developments of dendritic and hyperbranched based systems, together with their application as nanocarriers, have been comprehensively reviewed.
CONCLUSION
This review highlights how the structural complexity can be taken as an evolution parameter of these nanosystems, starting with hyperbranched polymers and evolving to more complex structures such as hybrid dendritic- inorganic nanoparticles and dendronized nano-objects hierarchically designed. Finally, future directions and perspectives in this promising field are briefly discussed.
背景
树状大分子和超支化聚合物是新兴的聚合物体系，由于其独特的拓扑结构和有趣的物理化学性质而引起越来越多的关注。它们巨大的潜力使它们特别适合形成新型迷人的纳米药物传递系统，解决纳米医学中遇到的几个典型缺点。
目的
在这种情况下，对基于树状大分子和超支化聚合物的系统的最新进展及其作为纳米载体的应用进行了全面综述。
结论
本文强调了结构复杂性如何可以作为这些纳米系统的演化参数，从超支化聚合物开始，演变为更复杂的结构，如杂化树枝状-无机纳米粒子和分级设计的树枝状纳米物体。最后，简要讨论了这个有前途的领域的未来方向和前景。
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