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调节性T细胞发育和功能的代谢控制

Metabolic control of regulatory T cell development and function.

作者信息

Zeng Hu, Chi Hongbo

机构信息

Department of Immunology, St. Jude Children's Research Hospital, Memphis, TN, USA.

Department of Immunology, St. Jude Children's Research Hospital, Memphis, TN, USA.

出版信息

Trends Immunol. 2015 Jan;36(1):3-12. doi: 10.1016/j.it.2014.08.003. Epub 2014 Sep 20.

DOI:10.1016/j.it.2014.08.003
PMID:25248463
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4280284/
Abstract

Foxp3(+) regulatory T cells (Tregs) maintain immune tolerance and play an important role in immunological diseases and cancers. Recent studies have revealed an intricate relationship between Treg biology and host and microbial metabolism. Various metabolites or nutrients produced by host and commensal microbes, such as vitamins and short-chain fatty acids (SCFAs), regulate Treg generation, trafficking, and function. Furthermore, cell intrinsic metabolic programs, orchestrated by mTOR and other metabolic sensors, modulate Foxp3 induction and Treg suppressive activity. Conversely, Tregs are crucial in regulating obesity-associated inflammation and host metabolic balance, and in shaping homeostasis of gut microbiota. We review here the interplay between Tregs and metabolism, with a particular focus on how host, commensal, and cellular metabolism impinge upon Treg homeostasis and function.

摘要

叉头框蛋白3（Foxp3）阳性调节性T细胞（Tregs）维持免疫耐受，并在免疫性疾病和癌症中发挥重要作用。最近的研究揭示了Treg生物学与宿主及微生物代谢之间的复杂关系。宿主和共生微生物产生的各种代谢产物或营养物质，如维生素和短链脂肪酸（SCFAs），可调节Treg的产生、迁移和功能。此外，由mTOR和其他代谢传感器精心编排的细胞内在代谢程序，可调节Foxp3的诱导和Treg的抑制活性。相反，Tregs在调节肥胖相关炎症和宿主代谢平衡以及塑造肠道微生物群稳态方面至关重要。我们在此综述Tregs与代谢之间的相互作用，特别关注宿主、共生和细胞代谢如何影响Treg的稳态和功能。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2744/4280284/5a54e9f99d92/nihms631668f3a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2744/4280284/a02abaf43f1a/nihms631668f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2744/4280284/7d81310c1a73/nihms631668f2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2744/4280284/5a54e9f99d92/nihms631668f3a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2744/4280284/a02abaf43f1a/nihms631668f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2744/4280284/7d81310c1a73/nihms631668f2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2744/4280284/5a54e9f99d92/nihms631668f3a.jpg

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本文引用的文献

1
Foxp3(+) T cells regulate immunoglobulin a selection and facilitate diversification of bacterial species responsible for immune homeostasis.Foxp3(+) T 细胞调节免疫球蛋白 A 的选择，并促进负责免疫稳态的细菌物种的多样化。
Immunity. 2014 Jul 17;41(1):152-65. doi: 10.1016/j.immuni.2014.05.016. Epub 2014 Jul 10.
2
The epigenetic regulator Uhrf1 facilitates the proliferation and maturation of colonic regulatory T cells.表观遗传调节因子 Uhrf1 促进结肠调节性 T 细胞的增殖和成熟。
Nat Immunol. 2014 Jun;15(6):571-9. doi: 10.1038/ni.2886. Epub 2014 Apr 28.
3
Segmented filamentous bacterium uses secondary and tertiary lymphoid tissues to induce gut IgA and specific T helper 17 cell responses.分段丝状菌利用二级和三级淋巴组织诱导肠道 IgA 和特定的辅助性 T 细胞 17 应答。
Immunity. 2014 Apr 17;40(4):608-20. doi: 10.1016/j.immuni.2014.03.009.
4
Focused specificity of intestinal TH17 cells towards commensal bacterial antigens.肠道 TH17 细胞对共生细菌抗原的特异性聚焦。
Nature. 2014 Jun 5;510(7503):152-6. doi: 10.1038/nature13279. Epub 2014 Apr 13.
5
Segmented filamentous bacteria antigens presented by intestinal dendritic cells drive mucosal Th17 cell differentiation.肠道树突状细胞呈递分段丝状菌抗原可驱动黏膜 Th17 细胞分化。
Immunity. 2014 Apr 17;40(4):594-607. doi: 10.1016/j.immuni.2014.03.005. Epub 2014 Mar 27.
6
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7
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9
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