Nicák A, Molnár A
Cas Lek Cesk. 1989 Oct 13;128(42):1318-20.
The reliability theory was elaborated for the estimation of the reliable action of technical systems. When it is applied to biological systems, it is important to characterize unequivocally the disorder which will substantially after the reliable activity of the entire organism or of individual systems. The authors investigated in their experiments during the postnatal development of rats changes in the erythrocyte stability. The age-conditioned decline was evaluated as a disorder. The erythrocyte stability was assessed in animals of different age, i. e. in 4-, 6-, 10-, 18- and 24-month-old animals by the method of the haemolytical action of brilliant cresyl blue in isotonic NaCl solution. The results of experiments suggest that when red cells were incubated in isotonic NaCl solution only, there was no difference in the lysis of erythrocytes in different age groups. However, when they were incubated in isotonic NaCl with brilliant cresyl blue, there was a significantly greater haemolysis in red cells of 4-, 18- and 24-month-old rats, as compared with the lysis of red cells from 6- and 10-month-old animals. Red cell lysis conditioned by brilliant cresyl blue in relation to age is discussed from the aspect of the reliability theory.
可靠性理论是为评估技术系统的可靠运行而阐述的。当将其应用于生物系统时，明确表征那种会在整个生物体或个体系统的可靠活动之后发生实质性变化的紊乱至关重要。作者在大鼠出生后的发育过程中，通过实验研究了红细胞稳定性的变化。将与年龄相关的下降评估为一种紊乱。采用灿烂甲酚蓝在等渗氯化钠溶液中的溶血作用方法，对不同年龄的动物，即4个月、6个月、10个月、18个月和24个月大的动物的红细胞稳定性进行了评估。实验结果表明，当红细胞仅在等渗氯化钠溶液中孵育时，不同年龄组的红细胞裂解没有差异。然而，当它们在含有灿烂甲酚蓝的等渗氯化钠溶液中孵育时，与6个月和10个月大动物的红细胞裂解相比，4个月、18个月和24个月大的大鼠的红细胞溶血明显更严重。从可靠性理论的角度讨论了灿烂甲酚蓝引起的红细胞裂解与年龄的关系。
