试点研究：骨髓干细胞用于治疗慢性脊髓损伤犬
Pilot study: bone marrow stem cells as a treatment for dogs with chronic spinal cord injury.
作者信息
Sarmento Carlos Alberto Palmeira, Rodrigues Marcio Nogueira, Bocabello Renato Zonzini, Mess Andrea Maria, Miglino Maria Angelica
机构信息
School of Veterinary Medicine and Animal Sciences, University of São Paulo, São Paulo, Brazil.
School of Veterinary Medicine and Animal Sciences, University of São Paulo, São Paulo, Brazil ; Cidade Universitaria-Butanta, Av. Prof. Orlando Marques de Paiva, 87, São Paulo, 05508270 Brazil.
出版信息
Regen Med Res. 2014 Dec 12;2(1):9. doi: 10.1186/2050-490X-2-9. eCollection 2014 Dec.
BACKGROUND
Chronic Spinal Cord injury is a common, severe, and medically untreatable disease. Since the functional outcomes of acute and experimental chronic spinal cord injury have been shown to improve with stem cell therapy, a case study was conducted to test if the application of stem cell also regenerates chronic SCI dysfunction. Transplantation of foetal bone marrow stem cells was applied in seven dogs with chronic spinal cord injury. Magnetic resonance images and assessments of symptoms according to the Olby scale were used to diagnose the severity of injury.
RESULT
All dogs improved locomotor and sensory function when examined 90 days after surgery, and showed increased movement of the hind limbs, and were able to stand upright, as well as to take small steps. Tail tone was observed in seven dogs, pain reflexes and defecation return were observed in five dogs.
CONCLUSION
The transplantation of bone marrow stem may be a promising, reliable and safe treatment for chronic spinal cord injury.
背景
慢性脊髓损伤是一种常见、严重且医学上无法治愈的疾病。由于急性和实验性慢性脊髓损伤的功能结果已显示通过干细胞疗法可得到改善，因此进行了一项案例研究，以测试干细胞的应用是否也能使慢性脊髓损伤功能障碍再生。将胎儿骨髓干细胞移植应用于7只患有慢性脊髓损伤的犬。使用磁共振成像和根据奥尔比量表对症状进行评估来诊断损伤的严重程度。
结果
所有犬在术后90天检查时运动和感觉功能均有改善，后肢运动增加，能够直立并迈出小步。7只犬观察到尾巴张力，5只犬观察到疼痛反射和排便恢复。
结论
骨髓干细胞移植可能是一种有前景、可靠且安全的慢性脊髓损伤治疗方法。
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