Ediriwickrema Asiri, Saltzman W Mark
Department of Biomedical Engineering, Yale University , 55 Prospect Street, MEC 414, New Haven, Connecticut 06511, United States.
ACS Biomater Sci Eng. 2015 Feb 9;1(2):64-78. doi: 10.1021/ab500084g. Epub 2015 Jan 13.
Cancer continues to be a prevalent and lethal disease, despite advances in tumor biology research and chemotherapy development. Major obstacles in cancer treatment arise from tumor heterogeneity, drug resistance, and systemic toxicities. Nanoscale delivery systems, or nanotherapies, are increasing in importance as vehicles for antineoplastic agents because of their potential for targeting and multifunctionality. We discuss the current field of cancer therapy and potential strategies for addressing obstacles in cancer treatment with nanotherapies. Specifically, we review the strategies for rationally designing nanoparticles for targeted, multimodal delivery of therapeutic agents.
尽管肿瘤生物学研究和化疗发展取得了进展，但癌症仍然是一种普遍且致命的疾病。癌症治疗中的主要障碍源于肿瘤异质性、耐药性和全身毒性。纳米级递送系统，即纳米疗法，作为抗肿瘤药物的载体，因其靶向性和多功能性的潜力而变得越来越重要。我们讨论了当前癌症治疗领域以及利用纳米疗法解决癌症治疗障碍的潜在策略。具体而言，我们回顾了合理设计纳米颗粒以实现治疗剂靶向、多模式递送的策略。
