Movement Disorders Program, Department of Clinical Neurosciences, University of Calgary, Calgary, Alberta, Canada.
Expert Rev Neurother. 2012 Feb;12(2):239-48. doi: 10.1586/ern.11.192.
The involvement of the autonomic nervous system in Parkinson's disease causes many non-motor symptoms, among which gastrointestinal complaints are prominent. Drooling, dyspepsia, constipation, abdominal pain and fecal incontinence are frequently a source of patient distress. Dysphagia is recognized as causing both discomfort and increased risk of serious complications. Although a diagnosis can often be established based on the reports of patients and/or caregivers, and additional testing is seldom required, these diagnoses are clearly under recognized in clinical practice. These symptoms respond to the same treatment measures used in the general population, although certain drugs with a potential to increase parkinsonian symptoms should be avoided. Increased and early identification of these symptoms can result in a significant improvement in the quality of life of Parkinson's disease patients.
自主神经系统在帕金森病中的参与导致许多非运动症状，其中胃肠道投诉尤为突出。流涎、消化不良、便秘、腹痛和粪便失禁经常是患者痛苦的根源。吞咽困难被认为既引起不适，又增加严重并发症的风险。虽然通常可以根据患者和/或护理者的报告做出诊断，并且很少需要额外的检查，但这些诊断在临床实践中显然没有得到充分认识。这些症状对一般人群中使用的相同治疗措施有反应，尽管某些有增加帕金森病症状潜力的药物应避免使用。增加和早期识别这些症状可以显著提高帕金森病患者的生活质量。
