Jurisic Kvesic A, Zavoreo I, Basic Kes V, Vucicevic Boras V, Ciliga D, Gabric D, Vrdoljak D V
Private Dental Practice, Zagreb, Croatia.
Clinic for Neurology, Clinical Hospital Centre Sisters of Mercy, Zagreb, Croatia.
Acupunct Med. 2015 Aug;33(4):289-92. doi: 10.1136/acupmed-2015-010759. Epub 2015 May 18.
Burning mouth syndrome (BMS) is a chronic oral condition, characterised by burning symptoms, which mainly affects perimenopausal and postmenopausal women. Neuropathy might be the underlying cause of the condition. There are still insufficient data regarding successful therapy. The aim of this study was to compare the effectiveness of acupuncture and clonazepam.
Forty-two patients with BMS (38 women, 4 men) aged 66.7±12.0 years were randomly divided into two groups. Acupuncture was performed on 20 participants over 4 weeks, 3 times per week, on points ST8, GB2, TE21, SI19, SI18 and LI4 bilaterally as well as GV20 in the midline, each session lasting half an hour. Twenty-two patients took clonazepam once a day (0.5 mg in the morning) for 2 weeks and, after 2 weeks, two tablets (0.5 mg in the morning and in the evening) were taken for the next 2 weeks. Prior to and 1 month after either therapy, participants completed questionnaires: visual analogue scale, Beck Depression Inventory, Leeds Assessment of Neuropathic Symptoms and Signs (LANSS) pain scale, 36-item Short Form Health Survey (SF-36) and Montreal Cognitive Assessment (MoCA).
There were significant improvements in the scores of all outcome measures after treatment with both acupuncture and clonazepam, except for MoCA. There were no significant differences between the two therapeutic regimens regarding the scores of the performed tests.
Acupuncture and clonazepam are similarly effective for patients with BMS.
灼口综合征（BMS）是一种慢性口腔疾病，以灼痛症状为特征，主要影响围绝经期和绝经后女性。神经病变可能是该疾病的潜在病因。关于成功治疗的数据仍然不足。本研究的目的是比较针灸和氯硝西泮的疗效。
42例年龄为66.7±12.0岁的BMS患者（38名女性，4名男性）被随机分为两组。20名参与者接受为期4周的针灸治疗，每周3次，双侧针刺ST8、GB2、TE21、SI19、SI18和LI4穴位以及中线的GV20穴位，每次治疗持续半小时。22名患者每天服用一次氯硝西泮（早上0.5毫克），持续2周，2周后，接下来的2周每天服用两片（早上和晚上各0.5毫克）。在两种治疗之前和之后1个月，参与者完成问卷调查：视觉模拟量表、贝克抑郁量表、利兹神经病变症状和体征评估（LANSS）疼痛量表、36项简短健康调查（SF - 36）和蒙特利尔认知评估（MoCA）。
除MoCA外，针灸和氯硝西泮治疗后所有结局指标的得分均有显著改善。两种治疗方案在所进行测试的得分方面没有显著差异。
针灸和氯硝西泮对BMS患者的疗效相似。
