Mendes Abreu João, Quitério Anabela, Cerqueira Érica, Ribeiro Rita, Nunes Tiago, Figueiredo José Pedro, Corte Real Ana
Faculty of Medicine, University of Coimbra, Coimbra, PRT.
Stomatology Service - Head, Neck, and Skin Surgery Department, Unidade Local de Saúde (ULS) de Coimbra, Coimbra, PRT.
Cureus. 2024 Sep 29;16(9):e70419. doi: 10.7759/cureus.70419. eCollection 2024 Sep.
The profound impact of burning mouth syndrome (BMS) on patients' quality of life (QoL) highlights the critical need to identify effective treatments for this condition. This study aims to evaluate and compare the health-related quality of life (HRQoL) and oral health-related quality of life (OHRQoL) among individuals diagnosed with BMS, focusing on different treatment modalities. For that purpose, a scoping review was designed following the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) for scoping review reporting guidelines and the registration with the International Prospective Register of Systematic Reviews (PROSPERO). An electronic search was then conducted in March 2024, encompassing the following databases: PubMed, Embase, Cochrane, Web of Science, and Trip Database. Publications were deemed eligible if they assessed the impact of different treatments for BMS on health-related and oral health-related QoL. Out of the initial 5400, only 13 studies were considered suitable to be included in this review. The instrument used to evaluate HRQoL was the 36-Item Short Form Survey (SF-36). For OHRQoL, the preferred tools were the Oral Health Impact Profile (OHIP) and the Geriatric Oral Health Assessment Index (GOHAI). Literature reported improvements in patients' HRQoL across the majority of analyzed treatment modalities. However, low-level laser therapy (LLLT) and n-acetylcysteine (NAC) plus clonazepam were the most effective in improving OHRQoL. This review highlights several promising treatment options for improving both HRQoL and OHRQoL in individuals with BMS. Nevertheless, the variability among the studies analyzed underscores the need for further research to identify and establish consistently effective treatments for this condition, reflecting the need for consistent trial designs to accurately assess the true impact of treatments on the disease.
灼口综合征（BMS）对患者生活质量（QoL）的深远影响凸显了确定针对该病症有效治疗方法的迫切需求。本研究旨在评估和比较被诊断为BMS的个体的健康相关生活质量（HRQoL）和口腔健康相关生活质量（OHRQoL），重点关注不同的治疗方式。为此，根据系统评价和Meta分析的首选报告项目（PRISMA）制定了范围综述报告指南，并在国际前瞻性系统评价注册库（PROSPERO）进行了注册。随后于2024年3月进行了电子检索，涵盖以下数据库：PubMed、Embase、Cochrane、科学网和Trip数据库。如果出版物评估了BMS不同治疗方法对健康相关和口腔健康相关QoL的影响，则被视为符合纳入标准。在最初的5400篇文献中，只有13项研究被认为适合纳入本综述。用于评估HRQoL的工具是36项简短调查（SF - 36）。对于OHRQoL，首选工具是口腔健康影响量表（OHIP）和老年口腔健康评估指数（GOHAI）。文献报道，在大多数分析的治疗方式中，患者的HRQoL有所改善。然而，低强度激光疗法（LLLT）以及N - 乙酰半胱氨酸（NAC）加氯硝西泮在改善OHRQoL方面最为有效。本综述强调了几种有望改善BMS患者HRQoL和OHRQoL的治疗选择。尽管如此，所分析研究之间的差异突出表明，需要进一步开展研究以确定并建立针对该病症始终有效的治疗方法，这反映出需要采用一致的试验设计来准确评估治疗对该疾病的真正影响。
