Qadri S M, Lee G, Brodie L
King Faisal Specialist Hospital, Riyadh, Saudi Arabia.
Drugs Exp Clin Res. 1989;15(8):349-53.
A total of 1724 clinical isolates from patients with different infections were tested in vitro to determine their susceptibility to norfloxacin. Antibacterial activity of norfloxacin was compared with other drugs that were commonly used in the hospital. Of the 919 strains of Enterobacteriaceae tested, all except four isolates of Enterobacter, two of Serratia and one of Proteus were susceptible to norfloxacin. Ninety-five percent of the 199 strains of Pseudomonas aeruginosa were also inhibited by this quinolone. Brucella melitensis (81 strains) was completely susceptible to norfloxacin. All the 250 isolates of Staphylococcus aureus and coagulase-negative staphylococci were also sensitive to norfloxacin. Pseudomonads other than P.aeruginosa, Acinetobacter/Alcaligenes and group D streptococci were less sensitive to norfloxacin, with 56%, 57% and 20% respectively being inhibited by this antimicrobial agent.
对来自不同感染患者的1724株临床分离株进行了体外测试，以确定它们对诺氟沙星的敏感性。将诺氟沙星的抗菌活性与医院常用的其他药物进行了比较。在测试的919株肠杆菌科细菌中，除4株阴沟肠杆菌、2株沙雷氏菌和1株变形杆菌外，所有菌株均对诺氟沙星敏感。199株铜绿假单胞菌中，95%也受到这种喹诺酮类药物的抑制。羊布鲁氏菌（81株）对诺氟沙星完全敏感。所有250株金黄色葡萄球菌和凝固酶阴性葡萄球菌对诺氟沙星也敏感。除铜绿假单胞菌外的假单胞菌、不动杆菌/产碱杆菌和D组链球菌对诺氟沙星不太敏感, 分别有56%、57%和20%被这种抗菌剂抑制。
