Tan Li-Zsa, Adams Susan E, Kennedy Alison, Kepreotes Helen, Ooi Chee Y
Li-Zsa Tan, Chee Y Ooi, Department of Gastroenterology, Sydney Children's Hospital, Randwick NSW 2031, Australia.
World J Gastroenterol. 2015 May 14;21(18):5751-4. doi: 10.3748/wjg.v21.i18.5751.
Children on exclusive jejunal feeding may be at risk of iron deficiency due to the feeds bypassing the duodenum, which is the primary site for iron absorption. We describe the biochemical and hematological features of six children on exclusive jejunal feeding who did not receive iron supplementation. At a mean (standard deviation) period of 11 (6.5) mo after commencing jejunal feeds, there was a significant reduction in both serum iron (18.5 g/L vs 9.8 g/L, P = 0.01) and transferrin saturation levels (23.1% vs 13.7%, P = 0.02), suggesting iron deficiency. However, there was no significant change in ferritin, hemoglobin and mean corpuscular volume levels post-commencement of jejunal feeds. This may be the result of small bowel adaptation in response to early iron deficiency. Larger and longer term prospective studies are required to investigate if children on jejunal feeds are at risk of developing iron deficiency.
由于空肠喂养绕过了十二指肠（铁吸收的主要部位），接受纯空肠喂养的儿童可能有缺铁风险。我们描述了6名未补充铁剂的接受纯空肠喂养儿童的生化和血液学特征。在开始空肠喂养后的平均（标准差）11（6.5）个月时，血清铁（18.5 g/L对9.8 g/L，P = 0.01）和转铁蛋白饱和度水平（23.1%对13.7%，P = 0.02）均显著降低，提示缺铁。然而，空肠喂养开始后，铁蛋白、血红蛋白和平均红细胞体积水平无显著变化。这可能是小肠对早期缺铁作出适应的结果。需要开展更大规模、更长期的前瞻性研究，以调查接受空肠喂养的儿童是否有发生缺铁的风险。
