长链非编码 RNA 在自身免疫性疾病中的新兴作用。

Emerging role of long noncoding RNAs in autoimmune diseases.

机构信息

Department of Epidemiology and Biostatistics, School of Public Health, Anhui Medical University, 81 Meishan Road, Hefei, 230032, Anhui, China; Anhui Provincial Laboratory of Population Health and Major Disease Screening and Diagnosis, Anhui Medical University, 81 Meishan Road, Hefei, 230032, Anhui, China.

Department of Nephrology, The Second Affiliated Hospital of Anhui Medical University, 678 Furong Road, Hefei, 230601, Anhui, China.

出版信息

Autoimmun Rev. 2015 Sep;14(9):798-805. doi: 10.1016/j.autrev.2015.05.004. Epub 2015 May 16.

DOI:10.1016/j.autrev.2015.05.004

PMID:25989481

Abstract

Long noncoding RNA (lncRNA), with size larger than 200 nucleotides, is a new class of noncoding RNA. Emerging evidence has revealed that lncRNAs play a key role in the regulation of immunological functions and autoimmunity. Herein, we review the recent findings of lncRNA regulation in immune functions and in the development of autoimmunity and autoimmune disease. In addition, we focus on the involvement of lncRNA regulation in innate and adaptive immune responses, immune cell development, and differential expression of lncRNAs in autoimmune diseases, including systemic lupus erythematosus (SLE), rheumatoid arthritis (RA), type 1 diabetes mellitus (T1DM), multiple sclerosis (MS), autoimmune thyroid disease (AITD), psoriasis, polymyositis/dermatomyositis (PM/DM) and Crohn's disease (CD).

摘要

长链非编码 RNA（lncRNA），大小大于 200 个核苷酸，是一类新的非编码 RNA。越来越多的证据表明，lncRNA 在免疫功能和自身免疫的调节中发挥着关键作用。本文综述了 lncRNA 在免疫功能和自身免疫及自身免疫性疾病发生发展中的调控作用。此外，我们还重点关注了 lncRNA 在固有免疫和适应性免疫反应、免疫细胞发育以及包括系统性红斑狼疮（SLE）、类风湿关节炎（RA）、1 型糖尿病（T1DM）、多发性硬化症（MS）、自身免疫性甲状腺疾病（AITD）、银屑病、多发性肌炎/皮肌炎（PM/DM）和克罗恩病（CD）在内的自身免疫性疾病中 lncRNA 调控的作用。