Mirzoian S A, Ekavian A G, Balasanian M G, Topchian A V
Farmakol Toksikol. 1989 Sep-Oct;52(5):41-3.
Pirrolidone-2, gamma-butyrolacton, succinic anhydride were found to possess pronounced antihypoxic activity that manifested itself in their ability to decrease the level of lactic acid accumulated during hypoxia. Pirrolidone-2 and succinic anhydride increase succinic dehydrogenase activity in vitro. At intraperitoneal administration the above mentioned compounds lead to lactate dehydrogenase activity inhibition under normal conditions while during circulatory hypoxia they stimulate lactate dehydrogenase reaction promoting the maintenance of energy balance of the cerebral tissue at the appropriate level.
发现吡咯烷酮 -2、γ-丁内酯、琥珀酸酐具有显著的抗缺氧活性，表现为它们能够降低缺氧期间积累的乳酸水平。吡咯烷酮 -2和琥珀酸酐在体外可提高琥珀酸脱氢酶的活性。腹腔注射上述化合物在正常条件下会导致乳酸脱氢酶活性受到抑制，而在循环性缺氧期间，它们会刺激乳酸脱氢酶反应，促进将脑组织的能量平衡维持在适当水平。
