Lobigs Louisa M, Knight Emma J, Schumacher Yorck Olaf, Gore Christopher J
Aspetar Orthopedic and Sports Medicine Hospital Doha, Qatar.
Sports Science, Exercise and Health, University of Western Australia, Perth, Western Australia.
Drug Test Anal. 2016 Feb;8(2):228-34. doi: 10.1002/dta.1809. Epub 2015 May 19.
The Athlete Biological Passport (ABP) estimates individualized reference ranges for key blood markers, such as haemoglobin concentration ([Hb]), using predetermined population mean, between- and within-subject variances. Here, we aim to reassess previously published estimates for within-subject [Hb] variance and determine whether sex-, analyzer-, sport-, or season-specific values are required. Our reference population contains 7723 male (mean ± SD, 22.3 ± 4.6 years of age) and 6164 female (21.6 ± 4.3) athlete observations from 49 sports. [Hb] was calculated using one of three cytometers; Bayer-H3 (1997-1999, n = 4554), ADVIA-120 (1999-2010, n = 8636) and Sysmex XT-2000i (2010-2012, n = 697). The final model was a linear mixed model for [Hb] with analyzer (H3, ADVIA, Sysmex), sex (male, female), sport (power-endurance, endurance, skill, team, disabled and non-athletes), season (summer, winter), and the interaction between sex and sport as fixed effects and athlete as a random effect. The model included an exponential correlation structure to allow for within-subject autocorrelation, and allowed different within-subject variances for each sport. Within-subject [Hb] variance (g(2) /L(2) ) was significantly less for power endurance (35.09, 95% CI 33.50 to 36.76), disabled (25.82, 95% CI 21.71 to 35.28) and non-athletes (34.30, 95% CI 28.53 to 35.87) than for endurance (40.35, 95% CI 39.62 to 47.22) and team sports (38.70, 95% CI 37.68 to 39.76) athletes. No new evidence was found to justify adjusting the current within-subject [Hb] variance estimate.
运动员生物护照（ABP）使用预先确定的总体均值、个体间和个体内方差，估算关键血液标志物（如血红蛋白浓度[Hb]）的个体参考范围。在此，我们旨在重新评估先前发表的个体内[Hb]方差估计值，并确定是否需要性别、分析仪、运动项目或季节特定的值。我们的参考人群包含来自49个运动项目的7723名男性（平均±标准差，22.3±4.6岁）和6164名女性（21.6±4.3岁）运动员的观察数据。[Hb]使用三种血细胞分析仪之一进行计算；拜耳H3（1997 - 1999年，n = 4554）、ADVIA - 120（1999 - 2010年，n = 8636）和Sysmex XT - 2000i（2010 - 2012年，n = 697）。最终模型是一个针对[Hb]的线性混合模型，其中分析仪（H3、ADVIA、Sysmex）、性别（男性、女性）、运动项目（力量耐力、耐力、技巧、团队、残疾人和非运动员）、季节（夏季、冬季）以及性别与运动项目之间的相互作用作为固定效应，运动员作为随机效应。该模型包括一个指数相关结构以考虑个体内自相关性，并允许每个运动项目有不同的个体内方差。力量耐力项目（35.09，95%置信区间33.50至3
