绵羊神经肽Y。一种高度保守肽的第三种结构类型。

Sheep neuropeptide Y. A third structural type of a highly conserved peptide.

作者信息

Sillard R, Agerberth B, Mutt V, Jörnvall H

机构信息

Department of Biochemistry II, Karolinska Institutet, Stockholm, Sweden.

出版信息

FEBS Lett. 1989 Dec 4;258(2):263-5. doi: 10.1016/0014-5793(89)81669-2.

DOI:10.1016/0014-5793(89)81669-2

PMID:2599092

Abstract

Mammalian forms of neuropeptide Y (NPY) for which the amino acid sequences have previously been determined, are the human, pig, ox, rabbit, rat, and guinea-pig polypeptides. The only difference among these forms is at position 17, where pig and ox NPY have Leu and the others Met. We now show that sheep NPY differs from all the earlier characterized mammalian forms of NPY by having Asp instead of Glu at position 10. At position 17 it has Leu as do both pig and ox NPY. Consequently, 3 different structural types of mammalian NPY are now known.

摘要

先前已确定氨基酸序列的哺乳动物神经肽Y（NPY）形式包括人、猪、牛、兔、大鼠和豚鼠的多肽。这些形式之间唯一的差异在第17位，猪和牛的NPY在此位置为亮氨酸（Leu），其他的为甲硫氨酸（Met）。我们现在表明，绵羊NPY与所有先前已鉴定的哺乳动物NPY形式不同，它在第10位是天冬氨酸（Asp）而不是谷氨酸（Glu）。在第17位，它与猪和牛的NPY一样是亮氨酸。因此，现在已知有3种不同结构类型的哺乳动物NPY。