Fuchs Yaron, Steller Hermann
1] Strang Laboratory of Apoptosis and Cancer Biology, Howard Hughes Medical Institute, The Rockefeller University, New York 10065, USA. [2] Laboratory of Stem Cell Biology and Regenerative Medicine, Department of Biology, Technion Israel Institute of Technology, Haifa 3200, Israel. [3] Lorry Lokey Interdisciplinary Center for Life Science, Technion Israel Institute of Technology, Haifa 3200, Israel.
Strang Laboratory of Apoptosis and Cancer Biology, Howard Hughes Medical Institute, The Rockefeller University, New York 10065, USA.
Nat Rev Mol Cell Biol. 2015 Jun;16(6):329-44. doi: 10.1038/nrm3999. Epub 2015 May 20.
All life ends in death, but perhaps one of life's grander ironies is that it also depends on death. Cell-intrinsic suicide pathways, termed programmed cell death (PCD), are crucial for animal development, tissue homeostasis and pathogenesis. Originally, PCD was almost synonymous with apoptosis; recently, however, alternative mechanisms of PCD have been reported. Here, we provide an overview of several distinct PCD mechanisms, namely apoptosis, autophagy and necroptosis. In addition, we discuss the complex signals that emanate from dying cells, which can either trigger regeneration or instruct additional killing. Further advances in understanding the physiological roles of the various mechanisms of cell death and their associated signals will be important to selectively manipulate PCD for therapeutic purposes.
所有生命都以死亡告终，但或许生命中一个更为宏大的讽刺是，它也依赖于死亡。被称为程序性细胞死亡（PCD）的细胞内在自杀途径对于动物发育、组织稳态和发病机制至关重要。最初，PCD几乎与凋亡同义；然而，最近已报道了PCD的其他机制。在这里，我们概述了几种不同的PCD机制，即凋亡、自噬和坏死性凋亡。此外，我们讨论了来自垂死细胞发出的复杂信号，这些信号既可以触发再生，也可以指示进一步的杀伤。在理解细胞死亡的各种机制及其相关信号的生理作用方面取得进一步进展，对于为治疗目的而选择性地操纵PCD将非常重要。
