Miziara Ivan, Chagury Azis, Vargas Camila, Freitas Ludmila, Mahmoud Ali
Department of Otolaryngology, Universidade de São Paulo, São Paulo, Brazil.
Int Arch Otorhinolaryngol. 2015 Jan;19(1):86-9. doi: 10.1055/s-0034-1378138. Epub 2014 Jul 9.
Introduction Burning mouth syndrome (BMS) is characterized by a burning sensation in the tongue, palate, lips, or gums of no well-defined etiology. The diagnosis and treatment for primary BMS are controversial. No specific laboratory tests or diagnostic criteria are well established, and the diagnosis is made by excluding all other possible disorders. Objective To review the literature on the main treatment options in idiopathic BMS and compare the best results of the main studies in 15 years. Data Synthesis We conducted a literature review on PubMed/MEDLINE, SciELO, and Cochrane-BIREME of work in the past 15 years, and only selected studies comparing different therapeutic options in idiopathic BMS, with preference for randomized and double-blind controlled studies. Final Comments Topical clonazepam showed good short-term results for the relief of pain, although this was not presented as a definitive cure. Similarly, α-lipoic acid showed good results, but there are few randomized controlled studies that showed the long-term results and complete remission of symptoms. On the other hand, cognitive therapy is reported as a good and lasting therapeutic option with the advantage of not having side effects, and it can be combined with pharmacologic therapy.
引言 灼口综合征（BMS）的特征是在舌头、上颚、嘴唇或牙龈出现烧灼感，病因不明。原发性BMS的诊断和治疗存在争议。目前尚未确立明确的实验室检查或诊断标准，诊断需排除所有其他可能的疾病。目的 回顾关于特发性BMS主要治疗选择的文献，并比较15年主要研究的最佳结果。资料综合 我们在PubMed/MEDLINE、SciELO和Cochrane-BIREME上对过去15年的研究进行了文献综述，仅选择了比较特发性BMS不同治疗方案的研究，优先选择随机双盲对照研究。最终评论 局部应用氯硝西泮在缓解疼痛方面显示出良好的短期效果，尽管这并非被视为一种根治方法。同样，α-硫辛酸也显示出良好效果，但很少有随机对照研究显示其长期效果和症状完全缓解情况。另一方面，认知疗法被报道为一种良好且持久的治疗选择，其优点是没有副作用，并且可以与药物治疗相结合。
