Department of Stomatology, University of Valencia, Valencia, Spain.
Med Oral Patol Oral Cir Bucal. 2012 Jan 1;17(1):e1-4. doi: 10.4317/medoral.17219.
To examine the efficacy of a new topical capsaicin presentation as an oral rinse in improving the symptoms of burning mouth syndrome (BMS).
A prospective, double-blind, cross-over study was made of 30 patients with BMS. There were 7 dropouts; the final study series thus comprised 23 individuals. The patients were randomized to two groups: (A) capsaicin rinse (0.02%) or (B) placebo rinse, administered during one week. After a one-week washout period, the patients were then assigned to the opposite group. Burning discomfort was scored using a visual analog scale (VAS): in the morning before starting the treatment, in the afternoon on the first day of treatment, and at the end of the week of treatment in the morning and in the afternoon. The same scoring sequence was again applied one week later with the opposite rinse.
The mean patient age was 72.65 ± 12.10 years, and the duration of BMS was 5.43 ± 3.23 years on average. Significant differences in VAS score were recorded in the capsaicin group between baseline in the morning (AM1) or afternoon (AA1) and the end of the week of treatment (AA7)(p=0.003 and p=0.002, respectively).
The topical application of capsaicin may be useful in treating the discomfort of BMS, but has some limitations.
研究一种新型局部辣椒素制剂作为口腔漱口液改善灼口综合征（BMS）症状的疗效。
对 30 例 BMS 患者进行前瞻性、双盲、交叉研究。有 7 例患者脱落；最终研究系列包括 23 名患者。患者随机分为两组：（A）辣椒素漱口液（0.02%）或（B）安慰剂漱口液，在一周内给药。经过一周的洗脱期后，患者被分配到相反的组。使用视觉模拟量表（VAS）对烧灼感进行评分：在开始治疗前的早晨、治疗第一天的下午以及治疗周结束时的早晨和下午。一周后，使用相反的漱口液再次应用相同的评分顺序。
患者的平均年龄为 72.65 ± 12.10 岁，BMS 的平均持续时间为 5.43 ± 3.23 年。在辣椒素组中，VAS 评分在基线时的早晨（AM1）或下午（AA1）与治疗周结束时（AA7）之间有显著差异（p=0.003 和 p=0.002）。
局部应用辣椒素可能对治疗 BMS 的不适症状有效，但存在一些局限性。
