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Tools for risk assessment in radiation therapy.放射治疗中的风险评估工具。
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Progress with Intensity-modulated radiotherapy implementation in the UK.英国调强放射治疗的实施进展
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Implementation of intensity-modulated radiotherapy: lessons learned and implications for the future.
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Evaluation of novel radiotherapy technologies: what evidence is needed to assess their clinical and cost effectiveness, and how should we get it?新型放射治疗技术的评估:评估其临床和成本效益需要哪些证据,我们应该如何获取?
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The physical basis and future of radiation therapy.放射治疗的物理基础与未来。
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Parotid-sparing intensity modulated versus conventional radiotherapy in head and neck cancer (PARSPORT): a phase 3 multicentre randomised controlled trial.腮腺保留调强放疗与常规放疗治疗头颈部肿瘤(PARSPORT):一项 3 期多中心随机对照试验。
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A review of the clinical evidence for intensity-modulated radiotherapy.调强放疗的临床证据回顾。
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在新放疗技术的实施上采取过于规避风险的方法会延迟其临床应用吗?

Does a too risk-averse approach to the implementation of new radiotherapy technologies delay their clinical use?

作者信息

Garcia R, Nyström H, Fiorino C, Thwaites D

机构信息

1 Physics Department, Institut Sainte Catherine, Avignon, France.

2 Medical Physics, Skandionkliniken, Uppsala, Sweden.

出版信息

Br J Radiol. 2015 Jul;88(1051):20150124. doi: 10.1259/bjr.20150124. Epub 2015 May 20.

DOI:10.1259/bjr.20150124
PMID:25993488
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4628537/
Abstract

Radiotherapy is a generally safe treatment modality in practice; nevertheless, recent well-reported accidents also confirm its potential risks. However, this may obstruct or delay the introduction of new technologies and treatment strategies/techniques into clinical practice. Risks must be addressed and judged in a realistic context: risks must be assessed realistically. Introducing new technology may introduce new possibilities of errors. However, delaying the introduction of such new technology therefore means that patients are denied the potentially better treatment opportunities. Despite the difficulty in quantitatively assessing the risks on both sides of the possible choice of actions, including the "lost opportunity", the best estimates should be included in the overall risk-benefit and cost-benefit analysis. Radiotherapy requires a sufficiently high level of support for the safety, precision and accuracy required: radiotherapy development and implementation is exciting. However, it has been anxious with a constant awareness of the consequences of mistakes or misunderstandings. Recent history can be used to show that for introduction of advanced radiotherapy, the risk-averse medical physicist can act as an electrical fuse in a complex circuit. The lack of sufficient medical physics resource or expertise can short out this fuse and leave systems unsafe. Future technological developments will continue to present further safety and risk challenges. The important evolution of radiotherapy brings different management opinions and strategies. Advanced radiotherapy technologies can and should be safely implemented in as timely a manner as possible for the patient groups where clinical benefit is indicated.

摘要

在实际应用中,放射治疗是一种总体安全的治疗方式;然而,近期大量报道的事故也证实了其潜在风险。然而,这可能会阻碍或延迟新技术及治疗策略/技术引入临床实践。必须在现实背景下处理和评判风险:必须切实评估风险。引入新技术可能会带来新的出错可能性。然而,推迟引入此类新技术意味着患者被剥夺了潜在的更好治疗机会。尽管难以对包括“错失机会”在内的可能行动选择的双方风险进行定量评估,但最佳估计应纳入总体风险效益和成本效益分析中。放射治疗需要对所需的安全性、精确性和准确性给予足够高度的支持:放射治疗的发展与实施令人兴奋。然而,人们一直忧心于对错误或误解后果的认知。近期的历史表明,对于先进放射治疗的引入,规避风险的医学物理师可在复杂电路中充当电保险丝。缺乏足够的医学物理资源或专业知识可能会使此保险丝熔断,从而使系统不安全。未来的技术发展将继续带来更多的安全和风险挑战。放射治疗的重要发展带来了不同的管理意见和策略。对于显示出临床获益的患者群体,先进放射治疗技术能够且应该尽可能及时地安全实施。