Raymond M, Heckel D G, Scott J G
Laboratoire de Génétique, Institut des Sciences de l'Evolution, Montpellier, France.
Genetics. 1989 Nov;123(3):543-51. doi: 10.1093/genetics/123.3.543.
In response to years of intense selection pressure by organophosphate insecticides, several different insecticide resistance mechanisms have evolved in natural populations of the mosquito Culex pipiens. We examined interactions between two of the most important mechanisms using a four-compartment model of insecticide pharmacokinetics. The joint effect of different mechanisms of resistance can be expressed in terms of epistasis at the physiological level in this model. The type of epistasis predicted by the model depends on the particular physiological mechanisms of resistance involved. Resistance due to a reduced penetration of the insecticide combines multiplicatively with other resistance factors, but resistance due to detoxicative processes and to insensitivity of the target site combines additively. How the pattern of epistasis at the physiological level is translated into fitness epistasis in natural populations of this mosquito depends on the intensity and pattern of insecticide selection in the field.
为应对有机磷杀虫剂多年来的强烈选择压力，致倦库蚊自然种群中已进化出几种不同的抗杀虫剂机制。我们使用杀虫剂药代动力学的四室模型研究了两种最重要机制之间的相互作用。在该模型中，不同抗性机制的联合效应可在生理水平上用上位性来表示。模型预测的上位性类型取决于所涉及的特定抗性生理机制。因杀虫剂穿透减少导致的抗性与其他抗性因素呈乘法结合，但因解毒过程和靶标位点不敏感导致的抗性呈加法结合。在这种蚊子的自然种群中，生理水平上的上位性模式如何转化为适合度上位性取决于田间杀虫剂选择的强度和模式。
