Slatkin M, Maddison W P
Department of Zoology, University of California, Berkeley 94720.
Genetics. 1989 Nov;123(3):603-13. doi: 10.1093/genetics/123.3.603.
A method for estimating the average level of gene flow among populations is introduced. The method provides an estimate of Nm, where N is the size of each local population in an island model and m is the migration rate. This method depends on knowing the phylogeny of the nonrecombining segments of DNA that are sampled. Given the phylogeny, the geographic location from which each sample is drawn is treated as multistate character with one state for each geographic location. A parsimony criterion applied to the evolution of this character on the phylogeny provides the minimum number of migration events consistent with the phylogeny. Extensive simulations show that the distribution of this minimum number is a simple function of Nm. Assuming the phylogeny is accurately estimated, this method provides an estimate of Nm that is as nearly as accurate as estimates obtained using FST and other statistics when Nm is moderate. Two examples of the use of this method with mitochondrial DNA data are presented.
介绍了一种估计种群间基因流平均水平的方法。该方法提供了Nm的估计值，其中N是岛屿模型中每个本地种群的大小，m是迁移率。此方法依赖于了解所采样的非重组DNA片段的系统发育。给定系统发育，将每个样本的地理位置视为多状态特征，每个地理位置对应一个状态。应用于该特征在系统发育上进化的简约标准提供了与系统发育一致的最小迁移事件数。广泛的模拟表明，这个最小数的分布是Nm的一个简单函数。假设系统发育估计准确，当Nm适中时，该方法提供的Nm估计值与使用FST和其他统计量获得的估计值几乎一样准确。给出了该方法用于线粒体DNA数据的两个示例。
