Deng Taoran, Lin Dandan, Zhang Man, Zhao Qingchuan, Li Weina, Zhong Bo, Deng Yu, Fu Xiangning
Department of Thoracic Surgery, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China The Second Clinical Medical Department, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China.
Department of Oncology, Renmin Hospital of Wuhan University, Wuhan University, Wuhan 430060, China.
Acta Biochim Biophys Sin (Shanghai). 2015 Jul;47(7):557-63. doi: 10.1093/abbs/gmv037. Epub 2015 May 20.
Bone morphogenetic proteins (BMPs) play important roles in tumor cell proliferation, metastasis, and invasion. However, the expression patterns of BMPs in patients with non-small-cell lung cancer (NSCLC) and their correlations with NSCLC pathogenesis have not been examined yet. In this study, the mRNA levels of BMP family members in NSCLC tissues were analyzed and results showed that the mRNA levels of BMP5 and BMP7 were significantly down-regulated and up-regulated, respectively, in tumor tissues compared with those in the corresponding noncancerous tissues. Interestingly, the mRNA level of BMP5 was significantly higher in lung adenocarcinoma tissues than that in lung squamous cell carcinoma tissues. Furthermore, results from immunohistochemistry analysis confirmed stronger expression of BMP5 protein in lung adenocarcinoma than in lung squamous cell carcinoma. Our findings suggested that BMP5 might be a potential prognostic biomarker or therapeutic target for patients with NSCLC.
骨形态发生蛋白（BMPs）在肿瘤细胞增殖、转移和侵袭中发挥重要作用。然而，非小细胞肺癌（NSCLC）患者中BMPs的表达模式及其与NSCLC发病机制的相关性尚未得到研究。在本研究中，分析了NSCLC组织中BMP家族成员的mRNA水平，结果显示，与相应的癌旁组织相比，肿瘤组织中BMP5和BMP7的mRNA水平分别显著下调和上调。有趣的是，肺腺癌组织中BMP5的mRNA水平显著高于肺鳞状细胞癌组织。此外，免疫组织化学分析结果证实，肺腺癌中BMP5蛋白的表达强于肺鳞状细胞癌。我们的研究结果表明，BMP5可能是NSCLC患者潜在的预后生物标志物或治疗靶点。
