Matsushita Mami, Yoneshiro Takeshi, Aita Sayuri, Kamiya Tomoyasu, Kusaba Nobutaka, Yamaguchi Kazuya, Takagaki Kinya, Kameya Toshimitsu, Sugie Hiroki, Saito Masayuki
Department of Nutrition, School of Nursing and Nutrition, Tenshi College.
J Nutr Sci Vitaminol (Tokyo). 2015;61(1):79-83. doi: 10.3177/jnsv.61.79.
Kaempferia parviflora extract (KP) has been reported to have a preventive effect on obesity in mice, probably by increasing energy expenditure (EE). The aims of the current study were to examine the acute effects of KP ingestion on whole-body EE in humans and to analyze its relation to the activity of brown adipose tissue (BAT), a site of non-shivering thermogenesis. After an oral ingestion of an ethanol extract of KP, EE increased significantly, showing a maximal increase of 229±69 kJ/d at 60 min, while it did not change after placebo ingestion. To evaluate BAT activity, the subjects underwent fluorodeoxyglucose-positron emission tomography, and divided into two groups with high- and low-BAT activities. A similar and greater response of EE to KP ingestion was observed in the high-BAT group (351±50 kJ/d at 60 min), but not in the low activity group. Placebo ingestion did not cause any significant EE change in either group. These results indicate that a single oral ingestion of the KP extract can potentially increase whole-body EE probably through the activation of BAT in healthy men, and may be useful as an anti-obesity regimen.
据报道，小花山柰提取物（KP）可能通过增加能量消耗（EE）对小鼠肥胖具有预防作用。本研究的目的是检测摄入KP对人体全身EE的急性影响，并分析其与非寒战产热部位棕色脂肪组织（BAT）活性的关系。口服KP乙醇提取物后，EE显著增加，在60分钟时最大增加量为229±69 kJ/天，而摄入安慰剂后EE没有变化。为了评估BAT活性，受试者接受了氟脱氧葡萄糖-正电子发射断层扫描，并被分为BAT活性高和低的两组。在BAT活性高的组中观察到EE对摄入KP有相似且更大的反应（60分钟时为351±50 kJ/天），而在低活性组中未观察到。摄入安慰剂在两组中均未引起EE的任何显著变化。这些结果表明，单次口服KP提取物可能通过激活健康男性的BAT潜在地增加全身EE，并且可能作为一种抗肥胖方案有用。
