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一名心脏移植受者发生致命性西尼罗河病毒脑炎

Fatal West Nile Virus Encephalitis in a Heart Transplant Recipient.

作者信息

Gomez Adam J, Waggoner Jesse J, Itoh Megumi, Hollander Seth A, Gutierrez Kathleen M, Budvytiene Indre, Banaei Niaz, Pinsky Benjamin A

机构信息

Department of Pathology, Stanford University School of Medicine, Stanford, California, USA.

Department of Medicine, Division of Infectious Diseases and Geographic Medicine, Stanford University School of Medicine, Stanford, California, USA.

出版信息

J Clin Microbiol. 2015 Aug;53(8):2749-52. doi: 10.1128/JCM.00834-15. Epub 2015 May 20.

DOI:10.1128/JCM.00834-15
PMID:25994169
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4508393/
Abstract

The diagnosis of encephalitis is particularly challenging in immunocompromised patients. We report here a case of fatal West Nile virus encephalitis confounded by the presence of budding yeast in the cerebrospinal fluid (CSF) from a patient who had undergone heart transplantation for dilated cardiomyopathy 11 months prior to presentation of neurologic symptoms.

摘要

对于免疫功能低下的患者,脑炎的诊断极具挑战性。我们在此报告一例致命的西尼罗河病毒脑炎病例,该病例因一名在出现神经症状前11个月因扩张型心肌病接受心脏移植的患者脑脊液(CSF)中存在出芽酵母而变得复杂。

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Mechanism of West Nile virus neuroinvasion: a critical appraisal.西尼罗河病毒神经侵袭机制:批判性评估
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West nile virus and other arboviral diseases - United States, 2013.西尼罗河病毒和其他虫媒病毒病 - 美国,2013 年。
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Genotype analyses of human commensal scalp fungi, Malassezia globosa, and Malassezia restricta on the scalps of patients with dandruff and healthy subjects.人类共生头皮真菌糠秕马拉色菌和限制马拉色菌的基因型分析,在头皮屑患者和健康受试者的头皮上。
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Clin Infect Dis. 2013 Oct;57(8):1114-28. doi: 10.1093/cid/cit458. Epub 2013 Jul 15.
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West Nile virus: review of the literature.西尼罗河病毒:文献综述。
JAMA. 2013 Jul 17;310(3):308-15. doi: 10.1001/jama.2013.8042.
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Unpredictable and difficult to control--the adolescence of West Nile virus.难以预测且难以控制——西尼罗河病毒的“青春期”。
N Engl J Med. 2012 Oct 4;367(14):1281-4. doi: 10.1056/NEJMp1210537. Epub 2012 Sep 26.
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Progress on the development of therapeutics against West Nile virus.抗西尼罗河病毒疗法的研发进展
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