Shashkova Sviatlana, Welkenhuysen Niek, Hohmann Stefan
Department of Chemistry and Molecular Biology, University of Gothenburg, 405 30 Göteborg, Sweden.
Department of Chemistry and Molecular Biology, University of Gothenburg, 405 30 Göteborg, Sweden
FEMS Yeast Res. 2015 Jun;15(4):fov026. doi: 10.1093/femsyr/fov026. Epub 2015 May 19.
The yeast Saccharomyces cerevisiae employs different conserved signaling pathways to adapt to altered availability of nutrient and energy sources. Crosstalk between the pathways occurs to integrate different internal and external stimuli and adjust cellular metabolism, growth and proliferation to altered environmental conditions. The main glucose repression pathway, Snf1/Mig1, plays an essential role in adaptation to glucose limitation. However, the Snf1 protein kinase is also involved in regulation of many other cellular processes. We summarize evidence that Snf1 is part of a network of communicating pathways, and we suggest research directions that may help elucidating signal flow within this network.
酿酒酵母利用不同的保守信号通路来适应营养和能量来源可用性的变化。这些通路之间会发生相互作用，以整合不同的内部和外部刺激，并根据环境条件的变化调整细胞代谢、生长和增殖。主要的葡萄糖抑制通路Snf1/Mig1在适应葡萄糖限制方面起着至关重要的作用。然而，Snf1蛋白激酶也参与调控许多其他细胞过程。我们总结了证据表明Snf1是相互连通的信号通路网络的一部分，并提出了可能有助于阐明该网络内信号流的研究方向。
