Manouchehrinia Ali, Edwards Laura J, Roshanisefat Homayoun, Tench Christopher R, Constantinescu Cris S
Division of Clinical Neuroscience, Clinical Neurology Research Group, University of Nottingham, Queen's Medical Centre, Nottingham, UK Department of Clinical Neuroscience, Karolinska Institute, Stockholm, Sweden.
Division of Clinical Neuroscience, Clinical Neurology Research Group, University of Nottingham, Queen's Medical Centre, Nottingham, UK.
BMJ Open. 2015 May 20;5(5):e007806. doi: 10.1136/bmjopen-2015-007806.
To determine if comorbid asthma is associated with accumulation of multiple sclerosis (MS)-related impairment and disability.
We sent a comprehensive questionnaire to a cohort of patients with MS and examined the association between comorbid asthma and reaching Expanded Disability Status Scale (EDSS) scores 4.0 and 6.0. Multiple Sclerosis Impact Scale (MSIS-29) scores were compared between patients with MS with and without comorbid asthma.
680 patients participated in our study of whom 88 (12.9%) had comorbid asthma. There was no difference in the prevalence of asthma between our MS cohort and the England general population (OR: 0.89, 95% CI 0.68 to 1.17). We did not observe a significant association between having asthma and the risk of reaching EDSS scores 4.0 and 6.0 (HR: 1.29, 95% CI 0.93 to 1.77, and HR: 1.33, 95% CI 0.93 to 1.89, respectively) after controlling for confounders. Patients with MS with asthma reported higher level of psychological impairments (coefficient: 2.29, 95% CI 0.1 to 4.49).
Asthma is a prevalent condition among patients with MS and it may contribute to the psychological impairment in MS. Although we did not observe significant association between comorbid asthma and physical disability in MS, it seems that the two conditions influence one another.
确定合并哮喘是否与多发性硬化症（MS）相关损伤和残疾的累积有关。
我们向一组MS患者发送了一份综合问卷，并研究了合并哮喘与扩展残疾状态量表（EDSS）评分达到4.0和6.0之间的关联。比较了合并哮喘和未合并哮喘的MS患者的多发性硬化症影响量表（MSIS - 29）评分。
680名患者参与了我们的研究，其中88名（12.9%）合并哮喘。我们的MS队列与英格兰普通人群的哮喘患病率无差异（OR：0.89，95%CI 0.68至1.17）。在控制混杂因素后，我们未观察到患哮喘与EDSS评分达到4.0和6.0的风险之间存在显著关联（HR分别为：1.29，95%CI 0.93至1.77；以及HR：1.33，95%CI 0.93至1.89）。合并哮喘患MS的患者报告心理损伤水平较高（系数：2.29，95%CI 0.1至4.49）。
哮喘在MS患者中很常见，可能导致MS患者的心理损伤。虽然我们未观察到合并哮喘与MS患者身体残疾之间存在显著关联，但这两种疾病似乎相互影响。
