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肥胖、胰内脂肪浸润与胰腺癌。

Obesity, Intrapancreatic Fatty Infiltration, and Pancreatic Cancer.

机构信息

Department of Gastrointestinal Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas.

Department of Pathology, The University of Texas MD Anderson Cancer Center, Houston, Texas. Department of Translational Molecular Pathology, The University of Texas MD Anderson Cancer Center, Houston, Texas. Sheikh Ahmed Bin Zayed Al Nahyan Center for Pancreatic Cancer Research, The University of Texas MD Anderson Cancer Center, Houston, Texas.

出版信息

Clin Cancer Res. 2015 Aug 1;21(15):3369-71. doi: 10.1158/1078-0432.CCR-15-0718. Epub 2015 May 20.

DOI:10.1158/1078-0432.CCR-15-0718
PMID:25995340
Abstract

Obesity and intrapancreatic fatty infiltration are associated with increased risk of pancreatic cancer and its precursor lesions. The interplay among obesity, inflammation, and oncogenic Kras signaling promotes pancreatic tumorigenesis. Targeting the interaction between obesity-associated inflammation and Kras signaling may provide new strategies for prevention and therapy of pancreatic cancer.

摘要

肥胖和胰内脂肪浸润与胰腺癌及其前体病变的风险增加有关。肥胖、炎症和致癌 Kras 信号之间的相互作用促进了胰腺肿瘤的发生。针对肥胖相关炎症和 Kras 信号之间的相互作用可能为胰腺癌的预防和治疗提供新的策略。

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