Tuna Zeynep, Duger Tulin, Atalay-Guzel Nevin, Aral Arzu, Basturk Bilkay, Haznedaroglu Seminur, Goker Berna
Department of Physiotherapy and Rehabilitation, Faculty of Health Sciences, Gazi University: Ankara 06500, Turkey.
Department of Physiotherapy and Rehabilitation, Faculty of Health Sciences, Hacettepe University, Turkey.
J Phys Ther Sci. 2015 Apr;27(4):1239-42. doi: 10.1589/jpts.27.1239. Epub 2015 Apr 30.
[Purpose] Although oxidative stress is known to be present in rheumatoid arthritis (RA), the effects of exercise on oxidative parameters are unknown. The aim of this study was to investigate the effects of acute aerobic exercise on serum oxidant and antioxidant levels in patients with RA. [Subjects and Methods] Sixteen patients with RA and 10 age-matched healthy volunteers participated in this study. All participants wore polar telemeters and walked on a treadmill for 30 minutes at a speed eliciting 60-75% of maximal heart rates. Blood samples were obtained before, immediately and 24 hours after exercise and malondialdehyde (MDA) and total sulfhydrile group (RSH) levels were measured. [Results] Both groups had similar heart rates during the test but the treadmill speed of the RA patients was significantly lower than that of the healthy volunteers. Serum MDA levels were lower than in both groups immediately after exercise, with greater decrements in the RA patients than controls. MDA levels returned to baseline 24 hours after the exercise only in the controls; they remained low in the RA patients. There was a slight increase in serum RSH levels after exercise compared to baseline in both groups. [Conclusion] Moderate intensity treadmill exercise did not have any adverse effect on the oxidant-antioxidant balance. The results suggest that such an exercise may be safely added to the rehabilitation program of RA for additional antioxidant effects. Morever, this antioxidant environment is maintained longer in RA patients.
[目的] 虽然已知氧化应激存在于类风湿关节炎（RA）中，但运动对氧化参数的影响尚不清楚。本研究的目的是调查急性有氧运动对RA患者血清氧化剂和抗氧化剂水平的影响。[对象与方法] 16例RA患者和10名年龄匹配的健康志愿者参与了本研究。所有参与者佩戴 Polar 遥测仪，在跑步机上以能引发最大心率60 - 75%的速度行走30分钟。在运动前、运动即刻和运动后24小时采集血样，测量丙二醛（MDA）和总巯基（RSH）水平。[结果] 两组在测试期间心率相似，但RA患者的跑步机速度显著低于健康志愿者。运动后即刻两组血清MDA水平均低于运动前，且RA患者的下降幅度大于对照组。仅对照组运动后24小时MDA水平恢复至基线；RA患者仍保持较低水平。与基线相比，两组运动后血清RSH水平均略有升高。[结论] 中等强度的跑步机运动对氧化剂 - 抗氧化剂平衡没有任何不良影响。结果表明，这种运动可安全地添加到RA康复计划中以获得额外的抗氧化作用。此外，RA患者的这种抗氧化环境维持时间更长。
