Department of Biochemistry, Sri Ramachandra Medical College and Research Institute, Sri Ramachandra University, Porur, Chennai, India.
Int J Rheum Dis. 2009 Apr;12(1):29-33. doi: 10.1111/j.1756-185X.2009.01375.x.
To assess the oxidative stress status in rheumatoid arthritis by measuring markers of free radical production, systemic activity of disease, free radical mediated tissue destruction and levels of antioxidant.
Peripheral blood samples were used for all the assays. Total nitric oxide (NO) was quantitatively measured using immunoassay kit. Malondialdehyde (MDA) and vitamin E were measured by spectrophotometric methods.
Statistically significant changes were observed in the levels of MDA, vitamin E, total NO and erythrocyte sedimentation rate (ESR) in the patient group. Significant differences were also observed in ESR and vitamin E levels in patients with active disease.
Increased oxidative stress status exists, which may lead to connective tissue degradation leading to joint and periarticular deformities in rheumatoid arthritis.
通过测量自由基生成、疾病全身活动、自由基介导的组织破坏和抗氧化剂水平的标志物来评估类风湿关节炎的氧化应激状态。
所有检测均使用外周血样。使用免疫试剂盒定量测定总一氧化氮 (NO)。采用分光光度法测定丙二醛 (MDA) 和维生素 E。
患者组 MDA、维生素 E、总 NO 和红细胞沉降率 (ESR) 水平均出现统计学显著变化。活动期患者的 ESR 和维生素 E 水平也存在显著差异。
类风湿关节炎存在氧化应激状态增加，这可能导致连接组织降解，导致关节和关节周围畸形。
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