Zhu Chunhui, Tang Yandong, Xu Fang, Zhou Jianhua
Bing Du Xue Bao. 2015 Jan;31(1):91-6.
Viperin is an endoplasmic reticulum (ER)-associated protein that has been identified as an innate antiviral protein. Viperin expression can be largely upregulated by viruses, interferons, and oligonucleotides such as poly I:C and lipopolysaccharides. Viperin inhibits viral replication by interactiing with host cell proteins and several viral proteins, and disrupting the cell membrane system. It shows a broad-spectrum of antiviral activity. Some viruses have developed activities that counteract the action of viperin during a long- term period of evolution with hosts by impairing viperin expression. In addition to its antiviral effects, viperin has several other biological functions. This article review the basic characteristics of viperin and the state of current research into its antiviral effects, demonstrating the rapid progress that has been made in this field.
蝰蛇毒蛋白是一种与内质网（ER）相关的蛋白质，已被鉴定为一种先天性抗病毒蛋白。蝰蛇毒蛋白的表达可被病毒、干扰素以及诸如聚肌胞苷酸和脂多糖等寡核苷酸大量上调。蝰蛇毒蛋白通过与宿主细胞蛋白和几种病毒蛋白相互作用并破坏细胞膜系统来抑制病毒复制。它具有广谱抗病毒活性。一些病毒在与宿主长期进化过程中通过损害蝰蛇毒蛋白的表达而产生了对抗蝰蛇毒蛋白作用的活性。除了其抗病毒作用外，蝰蛇毒蛋白还有其他几种生物学功能。本文综述了蝰蛇毒蛋白的基本特征及其抗病毒作用的当前研究状况，展示了该领域已取得的快速进展。
