储存式钙内流：机制与调节
Store-operated calcium entry: Mechanisms and modulation.
作者信息
Hogan Patrick G, Rao Anjana
机构信息
La Jolla Institute for Allergy & Immunology, 9420 Athena Circle, La Jolla, CA 92037, USA.
出版信息
Biochem Biophys Res Commun. 2015 Apr 24;460(1):40-9. doi: 10.1016/j.bbrc.2015.02.110.
Abstract
Store-operated calcium entry is a central mechanism in cellular calcium signalling and in maintaining cellular calcium balance. This review traces the history of research on store-operated calcium entry, the discovery of STIM and ORAI as central players in calcium entry, and the role of STIM and ORAI in biology and human disease. It describes current knowledge of the basic mechanism of STIM-ORAI signalling and of the varied mechanisms by which STIM-ORAI signalling can be modulated.
摘要
钙库操纵性钙内流是细胞钙信号传导和维持细胞钙平衡的核心机制。本综述追溯了钙库操纵性钙内流的研究历史、作为钙内流核心参与者的基质相互作用分子（STIM）和钙释放激活钙通道蛋白（ORAI）的发现，以及STIM和ORAI在生物学和人类疾病中的作用。它描述了目前关于STIM-ORAI信号传导基本机制以及STIM-ORAI信号传导可被调节的多种机制的知识。
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