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AMPK-TBC1D4-dependent mechanism for increasing insulin sensitivity of skeletal muscle.

作者信息

Cartee Gregory D

机构信息

Muscle Biology Laboratory, School of Kinesiology; Department of Molecular & Integrative Physiology; and Institute of Gerontology, University of Michigan, Ann Arbor, MI

出版信息

Diabetes. 2015 Jun;64(6):1901-3. doi: 10.2337/db15-0010.

DOI:10.2337/db15-0010
PMID:25999533
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4439559/
Abstract
摘要

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Prior AICAR stimulation increases insulin sensitivity in mouse skeletal muscle in an AMPK-dependent manner.预先给予AICAR刺激可通过AMPK依赖性方式增加小鼠骨骼肌的胰岛素敏感性。
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2
Increased postexercise insulin sensitivity is accompanied by increased AS160 phosphorylation in slow-twitch soleus muscle.运动后胰岛素敏感性增加伴随着慢肌比目鱼肌中AS160磷酸化增加。
Physiol Rep. 2014 Dec 11;2(12). doi: 10.14814/phy2.12162. Print 2014 Dec 1.
3
Roles of TBC1D1 and TBC1D4 in insulin- and exercise-stimulated glucose transport of skeletal muscle.
在胰岛素抵抗状态下，运动刺激葡萄糖摄取的生化和分子机制：炎症的作用。
Arq Bras Cardiol. 2019 Dec;113(6):1139-1148. doi: 10.5935/abc.20190224.
4
Electrical pulse stimulation induces differential responses in insulin action in myotubes from severely obese individuals.电脉冲刺激可诱导严重肥胖个体的肌管中胰岛素作用产生差异反应。
J Physiol. 2019 Jan;597(2):449-466. doi: 10.1113/JP276990. Epub 2018 Dec 2.
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Voluntary exercise opposes insulin resistance of skeletal muscle glucose transport during liquid fructose ingestion in rats.在大鼠摄入液态果糖期间，自愿运动可抵抗骨骼肌葡萄糖转运的胰岛素抵抗。
J Physiol Biochem. 2018 Aug;74(3):455-466. doi: 10.1007/s13105-018-0639-8. Epub 2018 Jun 7.
6
GLUT12 promotes prostate cancer cell growth and is regulated by androgens and CaMKK2 signaling.GLUT12 促进前列腺癌细胞生长，受雄激素和 CaMKK2 信号的调节。
Endocr Relat Cancer. 2018 Apr;25(4):453-469. doi: 10.1530/ERC-17-0051. Epub 2018 Feb 5.
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Diabetes. 2012 Nov;61(11):2743-52. doi: 10.2337/db11-1572. Epub 2012 Jul 30.
6
Mice with AS160/TBC1D4-Thr649Ala knockin mutation are glucose intolerant with reduced insulin sensitivity and altered GLUT4 trafficking.AS160/TBC1D4-Thr649Ala 敲入突变小鼠表现为葡萄糖不耐受，胰岛素敏感性降低，GLUT4 转运异常。
Cell Metab. 2011 Jan 5;13(1):68-79. doi: 10.1016/j.cmet.2010.12.005.
7
Exercise and insulin: Convergence or divergence at AS160 and TBC1D1?运动与胰岛素：在 AS160 和 TBC1D1 处趋同还是分歧？
Exerc Sport Sci Rev. 2009 Oct;37(4):188-95. doi: 10.1097/JES.0b013e3181b7b7c5.
8
Identification of a novel phosphorylation site on TBC1D4 regulated by AMP-activated protein kinase in skeletal muscle.鉴定骨骼肌中受 AMP 激活的蛋白激酶调控的 TBC1D4 上的一个新磷酸化位点。
Am J Physiol Cell Physiol. 2010 Feb;298(2):C377-85. doi: 10.1152/ajpcell.00297.2009. Epub 2009 Nov 18.
9
Increased AS160 phosphorylation, but not TBC1D1 phosphorylation, with increased postexercise insulin sensitivity in rat skeletal muscle.在大鼠骨骼肌中，随着运动后胰岛素敏感性增加，AS160磷酸化增加，但TBC1D1磷酸化未增加。
Am J Physiol Endocrinol Metab. 2009 Jul;297(1):E242-51. doi: 10.1152/ajpendo.00194.2009. Epub 2009 May 12.
10
Potential role of TBC1D4 in enhanced post-exercise insulin action in human skeletal muscle.TBC1D4在增强人体骨骼肌运动后胰岛素作用中的潜在作用。
Diabetologia. 2009 May;52(5):891-900. doi: 10.1007/s00125-009-1294-y. Epub 2009 Feb 28.