Weiskirchen Ralf, Mahli Abdo, Weiskirchen Sabine, Hellerbrand Claus
Institute of Molecular Pathobiochemistry, Experimental Gene Therapy and Clinical Chemistry, RWTH University Hospital Aachen Aachen, Germany.
Department of Internal Medicine I, University Hospital Regensburg Regensburg, Germany.
Front Physiol. 2015 May 6;6:140. doi: 10.3389/fphys.2015.00140. eCollection 2015.
Xanthohumol is the principal prenylated flavonoid of the female inflorescences of the hop plant. In recent years, various beneficial xanthohumol effects including anti-inflammatory, antioxidant, hypoglycemic activities, and anticancer effects have been revealed. This review summarizes present studies indicating that xanthohumol also inhibits several critical pathophysiological steps during the development and course of chronic liver disease, including the activation and pro-fibrogenic genotype of hepatic stellate cells. Also the various mechanism of action and molecular targets of the beneficial xanthohumol effects will be described. Furthermore, the potential use of xanthohumol or a xanthohumol-enriched hop extract as therapeutic agent to combat the progression of chronic liver disease will be discussed. It is notable that in addition to its hepatoprotective effects, xanthohumol also holds promise as a therapeutic agent for treating obesity, dysregulation of glucose metabolism and other components of the metabolic syndrome including hepatic steatosis. Thus, therapeutic xanthohumol application appears as a promising strategy, particularly in obese patients, to inhibit the development as well as the progression of non-alcoholic fatty liver disease.
黄腐酚是啤酒花植物雌花序中的主要异戊烯基化黄酮类化合物。近年来，已揭示出黄腐酚的多种有益作用，包括抗炎、抗氧化、降血糖活性和抗癌作用。本综述总结了目前的研究，表明黄腐酚还可抑制慢性肝病发生发展过程中的几个关键病理生理步骤，包括肝星状细胞的活化和促纤维化基因型。此外，还将描述黄腐酚有益作用的各种作用机制和分子靶点。此外，还将讨论黄腐酚或富含黄腐酚的啤酒花提取物作为治疗剂对抗慢性肝病进展的潜在用途。值得注意的是，除了其肝脏保护作用外，黄腐酚还有望作为治疗肥胖、葡萄糖代谢失调和代谢综合征其他成分（包括肝脂肪变性）的治疗剂。因此，黄腐酚的治疗应用似乎是一种有前景的策略，特别是在肥胖患者中，可抑制非酒精性脂肪性肝病的发生和进展。
