State Key Laboratory of Food Science and Technology, Medical School, Nanchang University, Bayi Road 461, Nanchang, Jiangxi Province, P. R. China.
Food Funct. 2015 Jun;6(6):1977-83. doi: 10.1039/c5fo00295h.
several studies have investigated the relationship between the estrogen receptor (ER) gene polymorphisms and the efficacy of estrogen replacement therapy in postmenopausal osteoporosis. However, the association of ER polymorphisms with the effects of dietary phytoestrogens on bone metabolism has not yet been reported. This study explores the possibility that ER alpha subtype (ERα) gene polymorphisms are involved in the effects of dietary phytoestrogens on bone mineral density (BMD) in postmenopausal women.
a total of 301 postmenopausal southern Chinese women were enrolled. Dietary phytoestrogen intake was evaluated using a food frequency questionnaire. ERα polymorphisms were examined with restriction fragment length polymorphism at the polymorphic PvuII and XbaI sites within intron 1. Dual-energy X-ray absorptiometry scans were performed to determine the BMD of the lumbar spine and hip.
the positive association of the lumbar spine BMD with dietary phytoestrogen intake was maintained only in groups with pp or xx genotypes (p < 0.05) and disappeared in groups with other genotypes. A positive association of the hip BMD with dietary phytoestrogen intake was observed only in the xx genotype group (p < 0.05).
the association of the dietary phytoestrogen intake and BMD in southern Chinese postmenopausal women varied with ERα gene polymorphisms.
多项研究已经调查了雌激素受体（ER）基因多态性与绝经后骨质疏松症雌激素替代治疗疗效之间的关系。然而，ER 多态性与植物雌激素对骨代谢的影响之间的关联尚未有报道。本研究探讨了 ER ɑ 亚型（ERα）基因多态性是否参与植物雌激素对绝经后妇女骨密度（BMD）的影响。
共纳入 301 名绝经后中国南方妇女。采用食物频率问卷评估植物雌激素的摄入量。使用内切酶 PvuII 和 XbaI 对位于内含子 1 中的多态性 PvuII 和 XbaI 位点进行 ERα 多态性检测。采用双能 X 线吸收仪测定腰椎和髋部的 BMD。
仅在 pp 或 xx 基因型组中（p<0.05），腰椎 BMD 与植物雌激素摄入量之间的正相关关系仍然存在，而在其他基因型组中则消失。髋部 BMD 与植物雌激素摄入量之间的正相关关系仅在 xx 基因型组中观察到（p<0.05）。
中国南方绝经后妇女的植物雌激素摄入量与 BMD 之间的关联因 ERα 基因多态性而异。
