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Oleocanthal Modulates Estradiol-Induced Gene Expression Involving Estrogen Receptor α.橄榄苦苷通过雌激素受体α调节雌二醇诱导的基因表达。
Planta Med. 2015 Sep;81(14):1263-9. doi: 10.1055/s-0035-1546194. Epub 2015 Jul 10.
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The adverse effect of 4-tert-octylphenol on fat metabolism in pregnant rats via regulation of lipogenic proteins.4-叔辛基苯酚通过调节生脂蛋白对孕鼠脂肪代谢的不良影响。
Environ Toxicol Pharmacol. 2015 Jul;40(1):284-91. doi: 10.1016/j.etap.2015.06.020. Epub 2015 Jun 22.
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Organophosphate insecticide use and cancer incidence among spouses of pesticide applicators in the Agricultural Health Study.农业健康研究中农药施用者配偶的有机磷杀虫剂使用情况与癌症发病率
Occup Environ Med. 2015 Oct;72(10):736-44. doi: 10.1136/oemed-2014-102798. Epub 2015 Jul 6.
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The flavonoid beverage Haelan 951 induces growth arrest and apoptosis in pancreatic carcinoma cell lines in vitro.类黄酮饮料Haelan 951在体外可诱导胰腺癌细胞系生长停滞和凋亡。
BMC Complement Altern Med. 2015 Jul 3;15:212. doi: 10.1186/s12906-015-0734-0.
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Perinatal exposure to chlordecone and infant growth.围产期接触十氯酮与婴儿生长
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Organochlorine pesticide levels in maternal blood and placental tissue with reference to preterm birth: a recent trend in North Indian population.与早产相关的孕妇血液和胎盘组织中的有机氯农药水平:北印度人群的最新趋势
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Bisphenol A affects placental layers morphology and angiogenesis during early pregnancy phase in mice.双酚A影响小鼠妊娠早期胎盘各层的形态及血管生成。
J Appl Toxicol. 2015 Nov;35(11):1278-91. doi: 10.1002/jat.3176. Epub 2015 Jun 9.
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Reporter Cell Lines for the Characterization of the Interactions between Human Nuclear Receptors and Endocrine Disruptors.用于表征人类核受体与内分泌干扰物之间相互作用的报告细胞系。
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In Vitro Effects of Bisphenol A β-D-Glucuronide (BPA-G) on Adipogenesis in Human and Murine Preadipocytes.双酚Aβ-D-葡萄糖醛酸苷(BPA-G)对人和小鼠前脂肪细胞脂肪生成的体外作用
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10
Association between dietary phytoestrogen intake and bone mineral density varied with estrogen receptor alpha gene polymorphisms in southern Chinese postmenopausal women.中国南方绝经后妇女饮食植物雌激素摄入与骨密度的关系与雌激素受体α基因多态性有关。
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与通过饮食接触外源性雌激素相关的风险和益处。

Risks and benefits related to alimentary exposure to xenoestrogens.

作者信息

Paterni Ilaria, Granchi Carlotta, Minutolo Filippo

机构信息

a Dipartimento di Farmacia , Università di Pisa , Pisa , Italy.

b Centro Interdipartimentale di Ricerca "Nutraceutica e Alimentazione per la Salute," Università di Pisa , Pisa , Italy.

出版信息

Crit Rev Food Sci Nutr. 2017 Nov 2;57(16):3384-3404. doi: 10.1080/10408398.2015.1126547.

DOI:10.1080/10408398.2015.1126547
PMID:26744831
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6104637/
Abstract

Xenoestrogens are widely diffused in the environment and in food, thus a large portion of human population worldwide is exposed to them. Among alimentary xenoestrogens, phytoestrogens (PhyEs) are increasingly being consumed because of their potential health benefits, although there are also important risks associated to their ingestion. Furthermore, other xenoestrogens that may be present in food are represented by other chemicals possessing estrogenic activities, that are commonly defined as endocrine disrupting chemicals (EDCs). EDCs pose a serious health concern since they may cause a wide range of health problems, starting from pre-birth till adult lifelong exposure. We herein provide an overview of the main classes of xenoestrogens, which are classified on the basis of their origin, their structures and their occurrence in the food chain. Furthermore, their either beneficial or toxic effects on human health are discussed in this review.

摘要

外源性雌激素在环境和食物中广泛分布,因此全球很大一部分人口都接触到它们。在食物中的外源性雌激素中,植物雌激素(PhyEs)因其潜在的健康益处而被越来越多地食用,尽管摄入它们也存在重大风险。此外,食物中可能存在的其他外源性雌激素是由具有雌激素活性的其他化学物质代表的,这些化学物质通常被定义为内分泌干扰物(EDCs)。内分泌干扰物引起了严重的健康问题,因为它们可能导致从出生前到成年期终身接触的广泛健康问题。我们在此概述了外源性雌激素的主要类别,这些类别是根据它们的来源、结构及其在食物链中的出现情况进行分类的。此外,本综述还讨论了它们对人类健康的有益或毒性作用。