Paterni Ilaria, Granchi Carlotta, Minutolo Filippo
a Dipartimento di Farmacia , Università di Pisa , Pisa , Italy.
b Centro Interdipartimentale di Ricerca "Nutraceutica e Alimentazione per la Salute," Università di Pisa , Pisa , Italy.
Crit Rev Food Sci Nutr. 2017 Nov 2;57(16):3384-3404. doi: 10.1080/10408398.2015.1126547.
Xenoestrogens are widely diffused in the environment and in food, thus a large portion of human population worldwide is exposed to them. Among alimentary xenoestrogens, phytoestrogens (PhyEs) are increasingly being consumed because of their potential health benefits, although there are also important risks associated to their ingestion. Furthermore, other xenoestrogens that may be present in food are represented by other chemicals possessing estrogenic activities, that are commonly defined as endocrine disrupting chemicals (EDCs). EDCs pose a serious health concern since they may cause a wide range of health problems, starting from pre-birth till adult lifelong exposure. We herein provide an overview of the main classes of xenoestrogens, which are classified on the basis of their origin, their structures and their occurrence in the food chain. Furthermore, their either beneficial or toxic effects on human health are discussed in this review.
外源性雌激素在环境和食物中广泛分布,因此全球很大一部分人口都接触到它们。在食物中的外源性雌激素中,植物雌激素(PhyEs)因其潜在的健康益处而被越来越多地食用,尽管摄入它们也存在重大风险。此外,食物中可能存在的其他外源性雌激素是由具有雌激素活性的其他化学物质代表的,这些化学物质通常被定义为内分泌干扰物(EDCs)。内分泌干扰物引起了严重的健康问题,因为它们可能导致从出生前到成年期终身接触的广泛健康问题。我们在此概述了外源性雌激素的主要类别,这些类别是根据它们的来源、结构及其在食物链中的出现情况进行分类的。此外,本综述还讨论了它们对人类健康的有益或毒性作用。