经验依赖性 DNA 甲基化调节发育中视觉皮层的可塑性。
Experience-dependent DNA methylation regulates plasticity in the developing visual cortex.
机构信息
Institute of Neuroscience CNR, Pisa, Italy.
1] Institute of Neuroscience CNR, Pisa, Italy. [2] BioSNS, Scuola Normale Superiore di Pisa, Pisa, Italy.
出版信息
Nat Neurosci. 2015 Jul;18(7):956-8. doi: 10.1038/nn.4026. Epub 2015 May 25.
DNA methylation is an epigenetic repressor mark for transcription dynamically regulated in neurons. We analyzed visual experience regulation of DNA methylation in mice and its involvement in ocular dominance plasticity of the developing visual cortex. Monocular deprivation modulated the expression of factors controlling DNA methylation and exerted opposite effects on DNA methylation and hydroxymethylation in specific plasticity genes. Inhibition of DNA methyltrasferase (DNMT) blocked molecular and functional effects of monocular deprivation, partially reversing the monocular deprivation transcriptional program.
DNA 甲基化是一种转录的表观遗传抑制标记，在神经元中动态调节。我们分析了 DNA 甲基化在小鼠中的视觉经验调节及其在发育中的视皮层眼优势可塑性中的作用。单眼剥夺调节了控制 DNA 甲基化的因素的表达，并对特定可塑性基因中的 DNA 甲基化和羟甲基化产生相反的影响。DNA 甲基转移酶 (DNMT) 的抑制阻断了单眼剥夺的分子和功能效应，部分逆转了单眼剥夺的转录程序。
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